3-amino-5,5-dimethyldihydrofuran-2(3H)-one hydrochloride (1:1)

Base Information

• Chemical Name: 3-amino-5,5-dimethyldihydrofuran-2(3H)-one hydrochloride (1:1)
• CAS No.: 15722-67-5
• Molecular Formula: C₆H₁₁NO₂*ClH
• Molecular Weight: 165.62
• Mol file: 15722-67-5.mol

Synonyms:2(3H)-Furanone,3-aminodihydro-5,5-dimethyl-, hydrochloride (8CI,9CI)

Chemical Property of 3-amino-5,5-dimethyldihydrofuran-2(3H)-one hydrochloride (1:1)

Chemical Property:

• Vapor Pressure: 0.0451mmHg at 25°C
• Boiling Point: 237.3°C at 760 mmHg
• Flash Point: 103.3°C
• PSA: 52.32000
• LogP: 1.54150

Purity/Quality:

99% ^*data from raw suppliers

3-amino-5,5-dimethyloxolan-2-onehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-amino-5,5-dimethyldihydrofuran-2(3H)-one hydrochloride (1:1)

There total 6 articles about 3-amino-5,5-dimethyldihydrofuran-2(3H)-one hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

DL-γ,δ-didehydroleucine (28024-78-4,905929-81-9) → 3-amino-5,5-dimethyltetrahydro-2-furanone (hydrochloride) (15722-67-5)

Guidance literature:

With hydrogenchloride; propionic acid; for 5h; Heating;

Reference yield:

(S)-2-Benzoylamino-4-fluoro-4-methyl-pentanoic acid ethyl ester (848949-91-7) → 3-amino-5,5-dimethyltetrahydro-2-furanone (hydrochloride) (15722-67-5)

Guidance literature:

With hydrogenchloride; In methanol; at 20 - 90 ℃;

DOI:10.1021/jo047918j

Reference yield:

4-(2-fluoro-2-methyl-propyl)-2-phenyl-4H-oxazol-5-one (848949-89-3) → 3-amino-5,5-dimethyltetrahydro-2-furanone (hydrochloride) (15722-67-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Novozyme-435; Et₃N / various solvent(s) / 4 h / 25 °C / Enzymatic reaction

2: HCl / methanol / 20 - 90 °C

With hydrogenchloride; novozyme-435; triethylamine; In methanol;

DOI:10.1021/jo047918j

upstream raw materials:

DL-γ,δ-didehydroleucine

(3R,5S)-4-Benzoyl-5-tert-butyl-1,1-dimethyl-6-oxa-4-aza-spiro[2.4]heptan-7-one

(S)-2-Benzoylamino-4-fluoro-4-methyl-pentanoic acid ethyl ester

4-(2-fluoro-2-methyl-propyl)-2-phenyl-4H-oxazol-5-one

Downstream raw materials:

4,4-dimethyl-2-(2,2,2-trifluoroacetamido)butyrolactone

L-γ-Methyl-α-(4-nitrobenzyloxycarbonylamino)-γ-valeriansaeurelacton

L-γ-Methyl-α-trifluoracetylamino-γ-valeriansaeurelacton

L-γ-Methyl-α-(p-tolylsulfonylamino)-γ-valeriansaeurelacton