848949-91-7Relevant articles and documents
An efficient chemoenzymatic approach to (S)-γ-fluoroleucine ethyl ester
Limanto, John,Shafiee, Ali,Devine, Paul N.,Upadhyay, Veena,Desmond, Richard A.,Foster, Bruce R.,Gauthier Jr., Donald R.,Reamer, Robert A.,Volante
, p. 2372 - 2375 (2007/10/03)
(Chemical Equation Presented) An asymmetric synthesis of (S)-γ-fluoroleucine ethyl ester 1 is described. The key transformation involves a lipase-catalyzed dynamic ring-opening of 2-(3-butenyl)azlactone 7b with EtOH to give amide ester (S)-6b in 84% enant