Technology Process of 5-(5-methoxy-2-(4-methoxyphenethyl)benzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
There total 5 articles about 5-(5-methoxy-2-(4-methoxyphenethyl)benzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triphenylphosphine / dichloromethane / 0.25 h / 0 °C
1.2: 0.55 h / 0 °C
1.3: 0.67 h / -78 °C
2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 4 h / 50 °C / Inert atmosphere
3.1: 10% palladium on activated carbon; hydrogen / ethyl acetate / 18 h / 760.05 Torr
4.1: pyrrolidine; acetic acid / benzene / 24 h / 20 °C
With
pyrrolidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 10% palladium on activated carbon; hydrogen; acetic acid; triethylamine; triphenylphosphine;
In
dichloromethane; ethyl acetate; benzene;
1.1: Corey-Fuchs homologation / 1.2: Corey-Fuchs homologation / 1.3: Corey-Fuchs homologation / 2.1: Sonogashira coupling / 4.1: Knoevenagel condensation;
DOI:10.1016/j.tetlet.2009.06.007
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 10% palladium on activated carbon; hydrogen / ethyl acetate / 18 h / 760.05 Torr
2: pyrrolidine; acetic acid / benzene / 24 h / 20 °C
With
pyrrolidine; 10% palladium on activated carbon; hydrogen; acetic acid;
In
ethyl acetate; benzene;
2: Knoevenagel condensation;
DOI:10.1016/j.tetlet.2009.06.007
