5-(5-methoxy-2-(4-methoxyphenethyl)benzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Base Information

Chemical Name:5-(5-methoxy-2-(4-methoxyphenethyl)benzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS No.:1185881-54-2
Molecular Formula:C₂₃H₂₄O₆
Molecular Weight:396.44
Hs Code.:

Synonyms:5-(5-methoxy-2-(4-methoxyphenethyl)benzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

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Chemical Property of 5-(5-methoxy-2-(4-methoxyphenethyl)benzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

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Technology Process of 5-(5-methoxy-2-(4-methoxyphenethyl)benzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

There total 5 articles about 5-(5-methoxy-2-(4-methoxyphenethyl)benzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 2033-24-1
cycl-isopropylidene malonate

: 1185881-89-3
2-(4-methoxyphenethyl)-5-methoxybenzaldehyde

: 1185881-54-2
5-(5-methoxy-2-(4-methoxyphenethyl)benzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Guidance literature:: With pyrrolidine; acetic acid; In benzene; at 20 ℃; for 24h;
DOI:10.1016/j.tetlet.2009.06.007

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1185881-54-2
5-(5-methoxy-2-(4-methoxyphenethyl)benzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine / dichloromethane / 0.25 h / 0 °C

1.2: 0.55 h / 0 °C

1.3: 0.67 h / -78 °C

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 4 h / 50 °C / Inert atmosphere

3.1: 10% palladium on activated carbon; hydrogen / ethyl acetate / 18 h / 760.05 Torr

4.1: pyrrolidine; acetic acid / benzene / 24 h / 20 °C

With pyrrolidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 10% palladium on activated carbon; hydrogen; acetic acid; triethylamine; triphenylphosphine; In dichloromethane; ethyl acetate; benzene; 1.1: Corey-Fuchs homologation / 1.2: Corey-Fuchs homologation / 1.3: Corey-Fuchs homologation / 2.1: Sonogashira coupling / 4.1: Knoevenagel condensation;
DOI:10.1016/j.tetlet.2009.06.007

Reference yield:

: 1185881-82-6
5-methoxy-2-(2-(4-methoxyphenyl)ethynyl)benzaldehyde

: 1185881-54-2
5-(5-methoxy-2-(4-methoxyphenethyl)benzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 10% palladium on activated carbon; hydrogen / ethyl acetate / 18 h / 760.05 Torr

2: pyrrolidine; acetic acid / benzene / 24 h / 20 °C

With pyrrolidine; 10% palladium on activated carbon; hydrogen; acetic acid; In ethyl acetate; benzene; 2: Knoevenagel condensation;
DOI:10.1016/j.tetlet.2009.06.007