2-(3-bromo-5-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}phenyl)-1,3-dioxolane

Base Information

Chemical Name:2-(3-bromo-5-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}phenyl)-1,3-dioxolane
CAS No.:936844-21-2
Molecular Formula:C₁₆H₂₃BrO₆
Molecular Weight:391.259
Hs Code.:

Synonyms:2-(3-bromo-5-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}phenyl)-1,3-dioxolane

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Chemical Property of 2-(3-bromo-5-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}phenyl)-1,3-dioxolane

Chemical Property:

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Technology Process of 2-(3-bromo-5-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}phenyl)-1,3-dioxolane

There total 7 articles about 2-(3-bromo-5-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}phenyl)-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 936844-20-1
3-bromo-5-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}benzaldehyde

: 107-21-1
ethylene glycol

: 936844-21-2
2-(3-bromo-5-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}phenyl)-1,3-dioxolane

Guidance literature:: With toluene-4-sulfonic acid; benzene; Heating;
DOI:10.1021/ja0690013

Reference yield:

: 355134-13-3
3-bromo-5-nitrobenzaldehyde

: 936844-21-2
2-(3-bromo-5-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}phenyl)-1,3-dioxolane

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / p-TsOH*H₂O / benzene / Heating

2: NEt₃; formic acid / Pt/C / 2 h / Heating

3: NaNO₂ / acetic acid; H₂O; H₂SO₄ / 0.5 h / 0 °C

4: 3.89 g / aq. sulfuric acid / acetic acid; H₂O / 0.08 h / Heating

5: 78 percent / K₂CO₃ / dimethylformamide / 72 h / 60 - 70 °C

6: 97 percent / TsOH*H₂O; benzene / Heating

With formic acid; sulfuric acid; potassium carbonate; toluene-4-sulfonic acid; triethylamine; sodium nitrite; benzene; platinum on activated charcoal; In sulfuric acid; water; acetic acid; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja0690013

Reference yield:

: 936844-18-7
2-(3-bromo-5-nitrophenyl)-1,3-dioxolane

: 936844-21-2
2-(3-bromo-5-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}phenyl)-1,3-dioxolane

Guidance literature:: Multi-step reaction with 5 steps

1: NEt₃; formic acid / Pt/C / 2 h / Heating

2: NaNO₂ / acetic acid; H₂O; H₂SO₄ / 0.5 h / 0 °C

3: 3.89 g / aq. sulfuric acid / acetic acid; H₂O / 0.08 h / Heating

4: 78 percent / K₂CO₃ / dimethylformamide / 72 h / 60 - 70 °C

5: 97 percent / TsOH*H₂O; benzene / Heating

With formic acid; sulfuric acid; potassium carbonate; toluene-4-sulfonic acid; triethylamine; sodium nitrite; benzene; platinum on activated charcoal; In sulfuric acid; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/ja0690013