5-amino-2-(2-(4-fluorophenoxy)ethyl)-thiazolo[5,4-d]pyrimidine-7-thiol

Base Information

• Chemical Name: 5-amino-2-(2-(4-fluorophenoxy)ethyl)-thiazolo[5,4-d]pyrimidine-7-thiol
• CAS No.: 1245316-55-5
• Molecular Formula: C₁₃H₁₁FN₄OS₂
• Molecular Weight: 322.387
• Mol file: 1245316-55-5.mol

Synonyms:5-amino-2-(2-(4-fluorophenoxy)ethyl)-thiazolo[5,4-d]pyrimidine-7-thiol

Chemical Property of 5-amino-2-(2-(4-fluorophenoxy)ethyl)-thiazolo[5,4-d]pyrimidine-7-thiol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-amino-2-(2-(4-fluorophenoxy)ethyl)-thiazolo[5,4-d]pyrimidine-7-thiol

There total 3 articles about 5-amino-2-(2-(4-fluorophenoxy)ethyl)-thiazolo[5,4-d]pyrimidine-7-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2-amino-4,6-dihydroxypyrimidin-5-yl)-3-(4-fluorophenoxy)propanamide (1245316-32-8) → 5-amino-2-(2-(4-fluorophenoxy)ethyl)-thiazolo[5,4-d]pyrimidine-7-thiol (1245316-55-5)

Guidance literature:

With pyridine; tetraphosphorus decasulfide; for 6h; Reflux;

DOI:10.1021/jm101254z

Reference yield:

3-(4-fluoro-phenoxy)propionic acid (1579-78-8) → 5-amino-2-(2-(4-fluorophenoxy)ethyl)-thiazolo[5,4-d]pyrimidine-7-thiol (1245316-55-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 20 °C

1.2: 0 - 20 °C

2.1: ethanol; sodium / 3 h / Reflux

3.1: pyridine; tetraphosphorus decasulfide / 6 h / Reflux

With pyridine; tetraphosphorus decasulfide; ethanol; sodium; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1021/jm101254z

Reference yield:

dimethyl 2-(3-(4-fluorophenoxy)propanamido)malonate (1245316-24-8) → 5-amino-2-(2-(4-fluorophenoxy)ethyl)-thiazolo[5,4-d]pyrimidine-7-thiol (1245316-55-5)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; sodium / 3 h / Reflux

2: pyridine; tetraphosphorus decasulfide / 6 h / Reflux

With pyridine; tetraphosphorus decasulfide; ethanol; sodium;

DOI:10.1021/jm101254z

upstream raw materials:

dimethyl 2-(3-(4-fluorophenoxy)propanamido)malonate

N-(2-amino-4,6-dihydroxypyrimidin-5-yl)-3-(4-fluorophenoxy)propanamide

3-(4-fluoro-phenoxy)propionic acid

Downstream raw materials:

2-(2-(4-fluorophenoxy)ethyl)-7-(methylsulfonyl)thiazolo[5,4-d]pyrimidin-5-amine

1-(4-(5-amino-2-(2-(4-fluorophenoxy)ethyl)thiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl)-2-(4-chlorophenoxy)ethanone

2-(2-(4-fluorophenoxy)ethyl)-7-(methylthio)thiazolo[5,4-d]-pyrimidin-5-amine