2-(2-(4-fluorophenoxy)ethyl)-7-(methylthio)thiazolo[5,4-d]-pyrimidin-5-amine

Base Information

• Chemical Name: 2-(2-(4-fluorophenoxy)ethyl)-7-(methylthio)thiazolo[5,4-d]-pyrimidin-5-amine
• CAS No.: 1245316-54-4
• Molecular Formula: C₁₄H₁₃FN₄OS₂
• Molecular Weight: 336.414
• Mol file: 1245316-54-4.mol

Synonyms:2-(2-(4-fluorophenoxy)ethyl)-7-(methylthio)thiazolo[5,4-d]-pyrimidin-5-amine

Chemical Property of 2-(2-(4-fluorophenoxy)ethyl)-7-(methylthio)thiazolo[5,4-d]-pyrimidin-5-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(4-fluorophenoxy)ethyl)-7-(methylthio)thiazolo[5,4-d]-pyrimidin-5-amine

There total 6 articles about 2-(2-(4-fluorophenoxy)ethyl)-7-(methylthio)thiazolo[5,4-d]-pyrimidin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

N-(2-amino-4,6-dihydroxypyrimidin-5-yl)-3-(4-fluorophenoxy)propanamide (1245316-32-8) + methyl iodide (74-88-4) → 2-(2-(4-fluorophenoxy)ethyl)-7-(methylthio)thiazolo[5,4-d]-pyrimidin-5-amine (1245316-54-4)

Guidance literature:

N-(2-amino-4,6-dihydroxypyrimidin-5-yl)-3-(4-fluorophenoxy)propanamide; With tetraphosphorus decasulfide; In pyridine; for 6h; Reflux;

methyl iodide; With triethylamine; In dimethyl sulfoxide; at 20 ℃; for 12h; Inert atmosphere;

Reference yield:

5-amino-2-(2-(4-fluorophenoxy)ethyl)-thiazolo[5,4-d]pyrimidine-7-thiol (1245316-55-5) + methyl iodide (74-88-4) → 2-(2-(4-fluorophenoxy)ethyl)-7-(methylthio)thiazolo[5,4-d]-pyrimidin-5-amine (1245316-54-4)

Guidance literature:

With triethylamine; In dimethyl sulfoxide; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jm101254z

Reference yield:

5-amino-2-(2-(4-fluorophenoxy)ethyl)-thiazolo[5,4-d]pyrimidine-7-thiol (1245316-55-5) + N-(2-amino-4,6-dihydroxypyrimidin-5-yl)-3-(4-fluorophenoxy)propanamide (1245316-32-8) + methyl iodide (74-88-4) → 2-(2-(4-fluorophenoxy)ethyl)-7-(methylthio)thiazolo[5,4-d]-pyrimidin-5-amine (1245316-54-4)

Guidance literature:

N-(2-amino-4,6-dihydroxypyrimidin-5-yl)-3-(4-fluorophenoxy)propanamide; With pyridine; tetraphosphorus decasulfide; for 6h; Reflux;

5-amino-2-(2-(4-fluorophenoxy)ethyl)-thiazolo[5,4-d]pyrimidine-7-thiol; methyl iodide; With triethylamine; In dimethyl sulfoxide; at 20 ℃; for 12h; Inert atmosphere;

upstream raw materials:

dimethyl 2-(3-(4-fluorophenoxy)propanamido)malonate

N-(2-amino-4,6-dihydroxypyrimidin-5-yl)-3-(4-fluorophenoxy)propanamide

5-amino-2-(2-(4-fluorophenoxy)ethyl)-thiazolo[5,4-d]pyrimidine-7-thiol

methyl iodide

Downstream raw materials:

2-(2-(4-fluorophenoxy)ethyl)-7-(methylsulfonyl)thiazolo[5,4-d]pyrimidin-5-amine

1-(4-(5-amino-2-(2-(4-fluorophenoxy)ethyl)thiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl)-2-(4-chlorophenoxy)ethanone