2-Chloro-4-dimethylamino-5-methanesulfonyl-benzoic acid methyl ester

Base Information

• Chemical Name: 2-Chloro-4-dimethylamino-5-methanesulfonyl-benzoic acid methyl ester
• CAS No.: 1012869-80-5
• Molecular Formula: C₁₁H₁₄ClNO₄S
• Molecular Weight: 291.755
• Mol file: 1012869-80-5.mol

Synonyms:2-Chloro-4-dimethylamino-5-methanesulfonyl-benzoic acid methyl ester

Chemical Property of 2-Chloro-4-dimethylamino-5-methanesulfonyl-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-Chloro-4-dimethylamino-5-methanesulfonyl-benzoic acid methyl ester

There total 2 articles about 2-Chloro-4-dimethylamino-5-methanesulfonyl-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

2-Chloro-4-fluoro-5-methanesulfonyl-benzoic acid methyl ester (33344-26-2) + N,N-dimethylammonium chloride (506-59-2) → 2-Chloro-4-dimethylamino-5-methanesulfonyl-benzoic acid methyl ester (1012869-80-5)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 65 ℃; for 15h; Autoclave;

Reference yield: 59.0%

2-Chloro-4-fluoro-5-methanesulfonyl-benzoic acid methyl ester (33344-26-2) + N,N-dimethylammonium chloride (506-59-2) + dimethyl sulfoxide (67-68-5,8070-53-9) → 2-Chloro-4-dimethylamino-5-methanesulfonyl-benzoic acid methyl ester (1012869-80-5)

Guidance literature:

With potassium carbonate;

Reference yield: 58.0%

2-Chloro-4-dimethylamino-5-methanesulfonyl-benzoic acid methyl ester (1012869-80-5) + methyl trifluoromethanesulfonate (333-27-7) → trifluoromethanesulfonate (5-chloro-2-methanesulfonyl-4-methoxycarbonylphenyl)trimethylammonium (1012869-82-7)

Guidance literature:

In dichloromethane; for 48h; Heating / reflux;

upstream raw materials:

2-Chloro-4-fluoro-5-methanesulfonyl-benzoic acid methyl ester

N,N-dimethylammonium chloride

dimethyl sulfoxide

Downstream raw materials:

trifluoromethanesulfonate (5-chloro-2-methanesulfonyl-4-methoxycarbonylphenyl)trimethylammonium