2-[3-[2-[2-(2-fluoroethoxy)ethoxy]ethoxy]-4-(methylamino)phenyl]-6-dimethylaminoquinoline

Base Information

Chemical Name:2-[3-[2-[2-(2-fluoroethoxy)ethoxy]ethoxy]-4-(methylamino)phenyl]-6-dimethylaminoquinoline
CAS No.:1374108-02-7
Molecular Formula:C₂₄H₃₀FN₃O₃
Molecular Weight:427.519
Hs Code.:

Synonyms:2-[3-[2-[2-(2-fluoroethoxy)ethoxy]ethoxy]-4-(methylamino)phenyl]-6-dimethylaminoquinoline

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Chemical Property of 2-[3-[2-[2-(2-fluoroethoxy)ethoxy]ethoxy]-4-(methylamino)phenyl]-6-dimethylaminoquinoline

Chemical Property:

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Technology Process of 2-[3-[2-[2-(2-fluoroethoxy)ethoxy]ethoxy]-4-(methylamino)phenyl]-6-dimethylaminoquinoline

There total 7 articles about 2-[3-[2-[2-(2-fluoroethoxy)ethoxy]ethoxy]-4-(methylamino)phenyl]-6-dimethylaminoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1374110-02-7
C₂₃H₂₈FN₃O₃

: 1374108-02-7
2-[3-[2-[2-(2-fluoroethoxy)ethoxy]ethoxy]-4-(methylamino)phenyl]-6-dimethylaminoquinoline

Guidance literature:: formaldehyd; C₂₃H₂₈FN₃O₃; With magnesium sulfate; In tetrahydrofuran; isopropyl alcohol; at 20 ℃; for 3h;

With sodium tetrahydroborate; In tetrahydrofuran; isopropyl alcohol; at 20 ℃; for 72h;

Reference yield:

: 6627-53-8
1-chloro-3-methoxy-4-nitrobenzene

: 1374108-02-7
2-[3-[2-[2-(2-fluoroethoxy)ethoxy]ethoxy]-4-(methylamino)phenyl]-6-dimethylaminoquinoline

Guidance literature:: Multi-step reaction with 7 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; tricyclohexylphosphine / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 16 h / 80 °C / Inert atmosphere

3.1: lithium chloride; N,N,N,N,N,N-hexamethylphosphoric triamide / 16 h / 110 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 96 h / 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C

6.1: ammonium formate; palladium 10% on activated carbon / methanol; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

7.1: magnesium sulfate / isopropyl alcohol; tetrahydrofuran / 3 h / 20 °C

7.2: 72 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; ammonium formate; potassium acetate; magnesium sulfate; potassium carbonate; lithium chloride; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 755026-96-1
2-(3-methoxy-4-nitrophenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

: 1374108-02-7
2-[3-[2-[2-(2-fluoroethoxy)ethoxy]ethoxy]-4-(methylamino)phenyl]-6-dimethylaminoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 16 h / 80 °C / Inert atmosphere

2.1: lithium chloride; N,N,N,N,N,N-hexamethylphosphoric triamide / 16 h / 110 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 96 h / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C

5.1: ammonium formate; palladium 10% on activated carbon / methanol; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

6.1: magnesium sulfate / isopropyl alcohol; tetrahydrofuran / 3 h / 20 °C

6.2: 72 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; ammonium formate; magnesium sulfate; potassium carbonate; lithium chloride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; isopropyl alcohol;