14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin hydrogenmaleate

Base Information

• Chemical Name: 14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin hydrogenmaleate
• CAS No.: 1350636-84-8
• Molecular Formula: C₄H₄O₄*C₂₈H₄₅NO₅S
• Molecular Weight: 623.808
• Mol file: 1350636-84-8.mol

Synonyms:14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin hydrogenmaleate

Chemical Property of 14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin hydrogenmaleate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin hydrogenmaleate

There total 20 articles about 14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin hydrogenmaleate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin (1061337-51-6) + maleic acid (110-16-7,26099-09-2) → 14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin hydrogenmaleate (1350636-84-8)

Guidance literature:

In tetrahydrofuran; ethyl acetate; at 20 - 80 ℃;

Reference yield:

pleuromutilin → 14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin hydrogenmaleate (1350636-84-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydroxide / dichloromethane / 20.33 h / 10 - 25 °C / Reflux; Industry scale

2.1: sodium hydroxide / benzyltri(n-butyl)ammonium chloride / water; tert-butyl methyl ether / 3 h / 17 - 23 °C / Industry scale

3.1: phosphoric acid / isopropyl alcohol / 16 h / 50 °C / Industry scale

3.2: 1.5 h / 0 - 25 °C / Industry scale

4.1: ethyl acetate; tetrahydrofuran / 20 - 80 °C

With phosphoric acid; sodium hydroxide; benzyltri(n-butyl)ammonium chloride; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether; water; ethyl acetate; isopropyl alcohol;

Reference yield:

pleuromutilin tosylate (31716-01-5) → 14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin hydrogenmaleate (1350636-84-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / benzyltri(n-butyl)ammonium chloride / water; tert-butyl methyl ether / 3 h / 17 - 23 °C / Industry scale

2.1: phosphoric acid / isopropyl alcohol / 16 h / 50 °C / Industry scale

2.2: 1.5 h / 0 - 25 °C / Industry scale

3.1: ethyl acetate; tetrahydrofuran / 20 - 80 °C

With phosphoric acid; sodium hydroxide; benzyltri(n-butyl)ammonium chloride; In tetrahydrofuran; tert-butyl methyl ether; water; ethyl acetate; isopropyl alcohol;

upstream raw materials:

14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin

maleic acid

(R)-cyclohex-3-enecarboxylic acid

pleuromutilin tosylate