14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin hydrogenmaleate

Base Information

Chemical Name:14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin hydrogenmaleate
CAS No.:1350636-84-8
Molecular Formula:C₄H₄O₄*C₂₈H₄₅NO₅S
Molecular Weight:623.808
Hs Code.:

Synonyms:14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin hydrogenmaleate

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Chemical Property of 14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin hydrogenmaleate

Chemical Property:

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Technology Process of 14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin hydrogenmaleate

There total 20 articles about 14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin hydrogenmaleate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1061337-51-6
14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin

: 110-16-7,26099-09-2
maleic acid

: 1350636-84-8
14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin hydrogenmaleate

Guidance literature:: In tetrahydrofuran; ethyl acetate; at 20 - 80 ℃;

Reference yield:

: pleuromutilin

: 1350636-84-8
14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin hydrogenmaleate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / dichloromethane / 20.33 h / 10 - 25 °C / Reflux; Industry scale

2.1: sodium hydroxide / benzyltri(n-butyl)ammonium chloride / water; tert-butyl methyl ether / 3 h / 17 - 23 °C / Industry scale

3.1: phosphoric acid / isopropyl alcohol / 16 h / 50 °C / Industry scale

3.2: 1.5 h / 0 - 25 °C / Industry scale

4.1: ethyl acetate; tetrahydrofuran / 20 - 80 °C

With phosphoric acid; sodium hydroxide; benzyltri(n-butyl)ammonium chloride; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether; water; ethyl acetate; isopropyl alcohol;

Reference yield:

: 31716-01-5
pleuromutilin tosylate

: 1350636-84-8
14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin hydrogenmaleate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / benzyltri(n-butyl)ammonium chloride / water; tert-butyl methyl ether / 3 h / 17 - 23 °C / Industry scale

2.1: phosphoric acid / isopropyl alcohol / 16 h / 50 °C / Industry scale

2.2: 1.5 h / 0 - 25 °C / Industry scale

3.1: ethyl acetate; tetrahydrofuran / 20 - 80 °C

With phosphoric acid; sodium hydroxide; benzyltri(n-butyl)ammonium chloride; In tetrahydrofuran; tert-butyl methyl ether; water; ethyl acetate; isopropyl alcohol;