n'-Benzylidene-2-hydroxybenzohydrazide

Base Information

• Chemical Name: n'-Benzylidene-2-hydroxybenzohydrazide
• CAS No.: 18269-02-8
• Molecular Formula: C₁₄H₁₂N₂O₂
• Molecular Weight: 240.261
• NSC Number: 148195
• ChEMBL ID: CHEMBL1962592
• Mol file: 18269-02-8.mol

Synonyms:n'-benzylidene-2-hydroxybenzohydrazide;NSC148195;CHEMBL1962592;18269-02-8;STK236463;AKOS000612244;NSC-148195;2-hydroxy-N'-[(1E)-phenylmethylene]benzohydrazide;2-hydroxy-N'-[(E)-phenylmethylidene]benzohydrazide;BRD-K47095280-001-01-9;Z49630404

Chemical Property of n'-Benzylidene-2-hydroxybenzohydrazide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.17g/cm³
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 240.089877630
• Heavy Atom Count: 18
• Complexity: 298

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C=NNC(=O)C2=CC=CC=C2O
• Isomeric SMILES: C1=CC=C(C=C1)/C=N/NC(=O)C2=CC=CC=C2O

Technology Process of n'-Benzylidene-2-hydroxybenzohydrazide

There total 9 articles about n'-Benzylidene-2-hydroxybenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzaldehyde (100-52-7) + 2-Hydroxybenzoylhydrazine (936-02-7) → N'-benzylidene-2-hydroxybenzohydrazide (59395-02-7,18269-02-8)

Guidance literature:

In ethanol; Reflux;

DOI:10.1021/jp110305k

Reference yield:

methyl salicylate (119-36-8,8024-54-2) → N'-benzylidene-2-hydroxybenzohydrazide (59395-02-7,18269-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol; water / 15 h / Reflux

2: acetic acid / ethanol / Reflux

With hydrazine hydrate; acetic acid; In ethanol; water;

DOI:10.1002/jhet.2516

Reference yield:

2-hydroxy-benzoic acid ethyl ester (118-61-6) → N'-benzylidene-2-hydroxybenzohydrazide (59395-02-7,18269-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / Reflux

2: ethanol / Reflux

With hydrazine hydrate; In ethanol;

DOI:10.1016/j.molstruc.2021.132058

upstream raw materials:

benzaldehyde

2-Hydroxybenzoylhydrazine

N'-(2-phenyl-2-ethylidene)-2-hydroxybenzohydrazide

methyl salicylate

Downstream raw materials:

2-(2-Oxo-1,2-dihydro-quinolin-4-ylmethoxy)-benzoic acid [1-phenyl-meth-(E)-ylidene]-hydrazide

benzaldehyde

2-Hydroxybenzoylhydrazine

2-Hydroxy-benzoic acid [1-(4-methoxy-phenylazo)-1-phenyl-meth-(Z)-ylidene]-hydrazide