1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid

Base Information

Chemical Name:1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid
CAS No.:1451802-53-1
Molecular Formula:C₂₀H₁₉ClFNO₃
Molecular Weight:375.827
Hs Code.:

Synonyms:1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid

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Chemical Property of 1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid

Chemical Property:

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Technology Process of 1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid

There total 8 articles about 1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1433407-87-4
1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid ethyl ester

: 1451802-53-1
1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; at 45 ℃;

Reference yield:

: 261762-82-7
6-chloro-2-fluoro-3-methylbenzoyl chloride

: 1451802-53-1
1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: tributylphosphine / tetrahydrofuran / 0.25 h / Inert atmosphere; Cooling

1.2: 0.75 h

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 22 h / 80 °C / Inert atmosphere

3.1: sodium hydrogencarbonate / dimethyl sulfoxide / 3 h / 80 °C

4.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

5.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 20 °C

6.1: dichloromethane / 72 h / 20 °C

7.1: sodium hydroxide / methanol / 45 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; tributylphosphine; sodium hydrogencarbonate; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1433409-07-4
(6-chloro-2-fluoro-3-methylphenyl)phenylmethanone

: 1451802-53-1
1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 22 h / 80 °C / Inert atmosphere

2: sodium hydrogencarbonate / dimethyl sulfoxide / 3 h / 80 °C

3: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: triphenylphosphine; carbon tetrabromide / dichloromethane / 20 °C

5: dichloromethane / 72 h / 20 °C

6: sodium hydroxide / methanol / 45 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; sodium hydrogencarbonate; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; dimethyl sulfoxide;