1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid amide hydrochloride

Base Information

Chemical Name:1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid amide hydrochloride
CAS No.:1433389-70-8
Molecular Formula:C₂₀H₂₀ClFN₂O₂*ClH
Molecular Weight:411.303
Hs Code.:

Synonyms:1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid amide hydrochloride

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Chemical Property of 1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid amide hydrochloride

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Technology Process of 1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid amide hydrochloride

There total 9 articles about 1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid amide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1451802-53-1
1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid

: 1433389-70-8
1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid amide hydrochloride

Guidance literature:: 1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid; With ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

With hydrogenchloride; In ethyl acetate;

Reference yield:

: 261762-82-7
6-chloro-2-fluoro-3-methylbenzoyl chloride

: 1433389-70-8
1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid amide hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: tributylphosphine / tetrahydrofuran / 0.25 h / Inert atmosphere; Cooling

1.2: 0.75 h

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 22 h / 80 °C / Inert atmosphere

3.1: sodium hydrogencarbonate / dimethyl sulfoxide / 3 h / 80 °C

4.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

5.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 20 °C

6.1: dichloromethane / 72 h / 20 °C

7.1: sodium hydroxide / methanol / 45 °C

8.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ammonium chloride / N,N-dimethyl-formamide / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; tributylphosphine; sodium hydrogencarbonate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1433409-07-4
(6-chloro-2-fluoro-3-methylphenyl)phenylmethanone

: 1433389-70-8
1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid amide hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 22 h / 80 °C / Inert atmosphere

2: sodium hydrogencarbonate / dimethyl sulfoxide / 3 h / 80 °C

3: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: triphenylphosphine; carbon tetrabromide / dichloromethane / 20 °C

5: dichloromethane / 72 h / 20 °C

6: sodium hydroxide / methanol / 45 °C

7: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ammonium chloride / N,N-dimethyl-formamide / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; sodium hydrogencarbonate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;