1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid ethyl ester

Base Information

Chemical Name:1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid ethyl ester
CAS No.:1433407-87-4
Molecular Formula:C₂₂H₂₃ClFNO₃
Molecular Weight:403.881
Hs Code.:

Synonyms:1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid ethyl ester

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Chemical Property of 1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid ethyl ester

Chemical Property:

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Technology Process of 1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid ethyl ester

There total 7 articles about 1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1433407-79-4
[3-(1-bromopropyl)-6-chloro-2-fluorophenyl]phenylmethanone

: 42303-42-4
ethyl 1-aminocyclopropanecarboxylate hydrochloride

: 1433407-87-4
1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid ethyl ester

Guidance literature:: In dichloromethane; at 20 ℃; for 72h;

Reference yield:

: 261762-82-7
6-chloro-2-fluoro-3-methylbenzoyl chloride

: 1433407-87-4
1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: tributylphosphine / tetrahydrofuran / 0.25 h / Inert atmosphere; Cooling

1.2: 0.75 h

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 22 h / 80 °C / Inert atmosphere

3.1: sodium hydrogencarbonate / dimethyl sulfoxide / 3 h / 80 °C

4.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

5.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 20 °C

6.1: dichloromethane / 72 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; tributylphosphine; sodium hydrogencarbonate; triphenylphosphine; In tetrahydrofuran; tetrachloromethane; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1433409-07-4
(6-chloro-2-fluoro-3-methylphenyl)phenylmethanone

: 1433407-87-4
1-[1-(3-benzoyl-4-chloro-2-fluorophenyl)propylamino]cyclopropanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 22 h / 80 °C / Inert atmosphere

2: sodium hydrogencarbonate / dimethyl sulfoxide / 3 h / 80 °C

3: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: triphenylphosphine; carbon tetrabromide / dichloromethane / 20 °C

5: dichloromethane / 72 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; sodium hydrogencarbonate; triphenylphosphine; In tetrahydrofuran; tetrachloromethane; dichloromethane; dimethyl sulfoxide;