1-ethyl-2-[[ethyl(phenyl)phosphinoyl]hydroxymethyl]imidazole

Base Information

• Chemical Name: 1-ethyl-2-[[ethyl(phenyl)phosphinoyl]hydroxymethyl]imidazole
• CAS No.: 475475-56-0
• Molecular Formula: C₁₄H₁₉N₂O₂P
• Molecular Weight: 278.291
• Mol file: 475475-56-0.mol

Synonyms:1-ethyl-2-[[ethyl(phenyl)phosphinoyl]hydroxymethyl]imidazole

Chemical Property of 1-ethyl-2-[[ethyl(phenyl)phosphinoyl]hydroxymethyl]imidazole

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 1-ethyl-2-[[ethyl(phenyl)phosphinoyl]hydroxymethyl]imidazole

There total 1 articles about 1-ethyl-2-[[ethyl(phenyl)phosphinoyl]hydroxymethyl]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(±)-ethyl(phenyl)phosphine oxide (21162-08-3) + 1-ethyl-2-formylimidazole (111851-98-0) → 1-ethyl-2-[[ethyl(phenyl)phosphinoyl]hydroxymethyl]imidazole (475475-56-0)

Guidance literature:

99; In 1,4-dioxane; at 20 ℃; for 1h;

DOI:10.1023/A:1014855309771

Reference yield: 39.0%

zinc(II) chloride (7646-85-7,24359-56-6) + 1-ethyl-2-[[ethyl(phenyl)phosphinoyl]hydroxymethyl]imidazole (475475-56-0) → ZnCl2(1-ethyl-2-[[ethyl(phenyl)phosphinoyl]hydroxymethyl]imidazole)2 (868261-35-2)

Guidance literature:

In ethanol; stirring of ZnCl2 (1 equiv.) and 1-ethyl-2-((ethyl(phenyl)phosphinoyl)hydroxymethyl)imidazole (2 equiv.) in abs. EtOH at 60°C for 8-15 h; pptn. with ether, drying, elem. anal.;

DOI:10.1007/s11176-005-0198-x

upstream raw materials:

(±)-ethyl(phenyl)phosphine oxide

1-ethyl-2-formylimidazole

Downstream raw materials:

ZnCl₂(1-ethyl-2-[[ethyl(phenyl)phosphinoyl]hydroxymethyl]imidazole)2