(2S,4R)-N-(benzyloxycarbonyl)-2-(tert-butoxymethyl)-4-methoxypyrrolidine

Base Information

Chemical Name:(2S,4R)-N-(benzyloxycarbonyl)-2-(tert-butoxymethyl)-4-methoxypyrrolidine
CAS No.:1372810-16-6
Molecular Formula:C₁₈H₂₇NO₄
Molecular Weight:321.417
Hs Code.:

Synonyms:(2S,4R)-N-(benzyloxycarbonyl)-2-(tert-butoxymethyl)-4-methoxypyrrolidine

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Chemical Property of (2S,4R)-N-(benzyloxycarbonyl)-2-(tert-butoxymethyl)-4-methoxypyrrolidine

Chemical Property:

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Technology Process of (2S,4R)-N-(benzyloxycarbonyl)-2-(tert-butoxymethyl)-4-methoxypyrrolidine

There total 3 articles about (2S,4R)-N-(benzyloxycarbonyl)-2-(tert-butoxymethyl)-4-methoxypyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.9%

: 335650-15-2
(2S,4R)-2-Hydroxymethyl-4-methoxy-pyrrolidine-1-carboxylic acid benzyl ester

: 115-11-7,15220-85-6
isobutene

: 1372810-16-6
(2S,4R)-N-(benzyloxycarbonyl)-2-(tert-butoxymethyl)-4-methoxypyrrolidine

Guidance literature:: With sulfuric acid; In dichloromethane; at 20 ℃; for 192h;
DOI:10.1002/ejoc.201101156

Reference yield:

: 64187-48-0
methyl (2S,4R)-1-benzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylate

: 1372810-16-6
(2S,4R)-N-(benzyloxycarbonyl)-2-(tert-butoxymethyl)-4-methoxypyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: silver(l) oxide / acetonitrile / 6 h / Reflux

2: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: sulfuric acid / dichloromethane / 192 h / 20 °C

With lithium borohydride; sulfuric acid; silver(l) oxide; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1002/ejoc.201101156

Reference yield:

: 96522-36-0
(2S,4R)-4-methoxypyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

: 1372810-16-6
(2S,4R)-N-(benzyloxycarbonyl)-2-(tert-butoxymethyl)-4-methoxypyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: sulfuric acid / dichloromethane / 192 h / 20 °C

With lithium borohydride; sulfuric acid; In tetrahydrofuran; dichloromethane;
DOI:10.1002/ejoc.201101156