3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-N-[(1S,2R)-2-hydroxy-3-({[3-(methyloxy)phenyl]methyl}amino)-1-(phenylmethyl)propyl]-5-[(1-methylethyl)amino]benzamide

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Chemical Name:3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-N-[(1S,2R)-2-hydroxy-3-({[3-(methyloxy)phenyl]methyl}amino)-1-(phenylmethyl)propyl]-5-[(1-methylethyl)amino]benzamide
CAS No.:870288-61-2
Molecular Formula:C₃₂H₄₁FN₄O₅S
Molecular Weight:612.766
Hs Code.:

3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-N-[(1S,2R)-2-hydroxy-3-({[3-(methyloxy)phenyl]methyl}amino)-1-(phenylmethyl)propyl]-5-[(1-methylethyl)amino]benzamide

Synonyms:3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-N-[(1S,2R)-2-hydroxy-3-({[3-(methyloxy)phenyl]methyl}amino)-1-(phenylmethyl)propyl]-5-[(1-methylethyl)amino]benzamide

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Chemical Property of 3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-N-[(1S,2R)-2-hydroxy-3-({[3-(methyloxy)phenyl]methyl}amino)-1-(phenylmethyl)propyl]-5-[(1-methylethyl)amino]benzamide

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Technology Process of 3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-N-[(1S,2R)-2-hydroxy-3-({[3-(methyloxy)phenyl]methyl}amino)-1-(phenylmethyl)propyl]-5-[(1-methylethyl)amino]benzamide

There total 7 articles about 3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-N-[(1S,2R)-2-hydroxy-3-({[3-(methyloxy)phenyl]methyl}amino)-1-(phenylmethyl)propyl]-5-[(1-methylethyl)amino]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 706795-00-8
3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-5-[(1-methylethyl)amino]-benzoic acid

: (2R,3S)-3-amino-1-({[3-(methyloxy)phenyl]methyl}amino)-4-phenyl-2-butanol bis(4-methylbenzenesulfonate)

: 870288-61-2
3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-N-[(1S,2R)-2-hydroxy-3-({[3-(methyloxy)phenyl]methyl}amino)-1-(phenylmethyl)propyl]-5-[(1-methylethyl)amino]benzamide

Guidance literature:: 3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-5-[(1-methylethyl)amino]-benzoic acid; (2R,3S)-3-amino-1-({[3-(methyloxy)phenyl]methyl}amino)-4-phenyl-2-butanol bis(4-methylbenzenesulfonate); With N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 706792-66-7
methyl 5-amino-3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluorobenzoate

: 870288-61-2
3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-N-[(1S,2R)-2-hydroxy-3-({[3-(methyloxy)phenyl]methyl}amino)-1-(phenylmethyl)propyl]-5-[(1-methylethyl)amino]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane; water / 1 h / 20 °C

2.1: methanol; sodium hydroxide; water / 1.5 h / Heating / reflux

2.2: pH 6

3.1: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With N-ethylmorpholine;; methanol; sodium hydroxide; water; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water;

Reference yield:

: 706792-62-3
methyl 3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-5-nitrobenzoate

: 870288-61-2
3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-N-[(1S,2R)-2-hydroxy-3-({[3-(methyloxy)phenyl]methyl}amino)-1-(phenylmethyl)propyl]-5-[(1-methylethyl)amino]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: iron; acetic acid / water / 2 h / 50 °C

2.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane; water / 1 h / 20 °C

3.1: methanol; sodium hydroxide; water / 1.5 h / Heating / reflux

3.2: pH 6

4.1: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With N-ethylmorpholine;; methanol; sodium hydroxide; water; sodium tris(acetoxy)borohydride; iron; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water;