1,1-dimethylethyl {(2R,3S)-3-[({3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-5-[(1-methylethyl)amino]phenyl}carbonyl)amino]-2-hydroxy-4-phenylbutyl}{[3-(methyloxy)phenyl]methyl}carbamate

Base Information

Chemical Name:1,1-dimethylethyl {(2R,3S)-3-[({3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-5-[(1-methylethyl)amino]phenyl}carbonyl)amino]-2-hydroxy-4-phenylbutyl}{[3-(methyloxy)phenyl]methyl}carbamate
CAS No.:870288-62-3
Molecular Formula:C₃₇H₄₉FN₄O₇S
Molecular Weight:712.883
Hs Code.:

1,1-dimethylethyl {(2R,3S)-3-[({3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-5-[(1-methylethyl)amino]phenyl}carbonyl)amino]-2-hydroxy-4-phenylbutyl}{[3-(methyloxy)phenyl]methyl}carbamate

Synonyms:1,1-dimethylethyl {(2R,3S)-3-[({3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-5-[(1-methylethyl)amino]phenyl}carbonyl)amino]-2-hydroxy-4-phenylbutyl}{[3-(methyloxy)phenyl]methyl}carbamate

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Chemical Property of 1,1-dimethylethyl {(2R,3S)-3-[({3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-5-[(1-methylethyl)amino]phenyl}carbonyl)amino]-2-hydroxy-4-phenylbutyl}{[3-(methyloxy)phenyl]methyl}carbamate

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Technology Process of 1,1-dimethylethyl {(2R,3S)-3-[({3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-5-[(1-methylethyl)amino]phenyl}carbonyl)amino]-2-hydroxy-4-phenylbutyl}{[3-(methyloxy)phenyl]methyl}carbamate

There total 10 articles about 1,1-dimethylethyl {(2R,3S)-3-[({3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-5-[(1-methylethyl)amino]phenyl}carbonyl)amino]-2-hydroxy-4-phenylbutyl}{[3-(methyloxy)phenyl]methyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 870288-61-2
3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-N-[(1S,2R)-2-hydroxy-3-({[3-(methyloxy)phenyl]methyl}amino)-1-(phenylmethyl)propyl]-5-[(1-methylethyl)amino]benzamide

: 24424-99-5
di-tert-butyl dicarbonate

: 870288-62-3
1,1-dimethylethyl {(2R,3S)-3-[({3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-5-[(1-methylethyl)amino]phenyl}carbonyl)amino]-2-hydroxy-4-phenylbutyl}{[3-(methyloxy)phenyl]methyl}carbamate

Guidance literature:: In dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

: 706792-66-7
methyl 5-amino-3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluorobenzoate

: 870288-62-3
1,1-dimethylethyl {(2R,3S)-3-[({3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-5-[(1-methylethyl)amino]phenyl}carbonyl)amino]-2-hydroxy-4-phenylbutyl}{[3-(methyloxy)phenyl]methyl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane; water / 1 h / 20 °C

2.1: methanol; sodium hydroxide; water / 1.5 h / Heating / reflux

2.2: pH 6

3.1: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

4.1: dichloromethane / 1.5 h / 20 °C

With N-ethylmorpholine;; methanol; sodium hydroxide; water; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water;

Reference yield:

: 706792-62-3
methyl 3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-5-nitrobenzoate

: 870288-62-3
1,1-dimethylethyl {(2R,3S)-3-[({3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-5-[(1-methylethyl)amino]phenyl}carbonyl)amino]-2-hydroxy-4-phenylbutyl}{[3-(methyloxy)phenyl]methyl}carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: iron; acetic acid / water / 2 h / 50 °C

2.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane; water / 1 h / 20 °C

3.1: methanol; sodium hydroxide; water / 1.5 h / Heating / reflux

3.2: pH 6

4.1: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

5.1: dichloromethane / 1.5 h / 20 °C

With N-ethylmorpholine;; methanol; sodium hydroxide; water; sodium tris(acetoxy)borohydride; iron; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water;