1-tert-butyl 4-{[({trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexyl}carbonyl)oxy]methyl}piperidine-1,4-dicarboxylate

Base Information

Chemical Name:1-tert-butyl 4-{[({trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexyl}carbonyl)oxy]methyl}piperidine-1,4-dicarboxylate
CAS No.:1609978-82-6
Molecular Formula:C₃₈H₄₇F₂N₅O₇
Molecular Weight:723.817
Hs Code.:

1-tert-butyl 4-{[({trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexyl}carbonyl)oxy]methyl}piperidine-1,4-dicarboxylate

Synonyms:1-tert-butyl 4-{[({trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexyl}carbonyl)oxy]methyl}piperidine-1,4-dicarboxylate

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Chemical Property of 1-tert-butyl 4-{[({trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexyl}carbonyl)oxy]methyl}piperidine-1,4-dicarboxylate

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Technology Process of 1-tert-butyl 4-{[({trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexyl}carbonyl)oxy]methyl}piperidine-1,4-dicarboxylate

There total 11 articles about 1-tert-butyl 4-{[({trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexyl}carbonyl)oxy]methyl}piperidine-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421930-35-9
trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylic acid

: 150109-49-2
1-tert-butyl 4-(chloromethyl)piperidine-1,4-dicarboxylate

: 1609978-82-6
1-tert-butyl 4-{[({trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexyl}carbonyl)oxy]methyl}piperidine-1,4-dicarboxylate

Guidance literature:: trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylic acid; With potassium carbonate; In N,N-dimethyl-formamide; for 0.166667h;

With sodium iodide; In N,N-dimethyl-formamide; for 0.333333h;

1-tert-butyl 4-(chloromethyl)piperidine-1,4-dicarboxylate; In N,N-dimethyl-formamide; for 20h;

Reference yield:

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 1609978-82-6
1-tert-butyl 4-{[({trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexyl}carbonyl)oxy]methyl}piperidine-1,4-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h

1.2: 20 h

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h

2.2: 0.33 h

2.3: 20 h

With potassium carbonate; caesium carbonate; In N,N-dimethyl-formamide;

Reference yield:

: 32529-80-9,36218-60-7
trans-1-chlorocarbonyl-4-(methoxycarbonyl)-cyclohexane

: 1609978-82-6
1-tert-butyl 4-{[({trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexyl}carbonyl)oxy]methyl}piperidine-1,4-dicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene / 3 h / 15 - 20 °C / Cooling with ice

2.1: isopropylmagnesium chloride / tetrahydrofuran; dichloromethane / 0.67 h / 0 - 5 °C

2.2: 2.25 h / 0 °C

2.3: 0 - 20 °C

3.1: ChiralPak AD-10 urn, 300x50 mm ID / ethanol / Resolution of racemate

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; bis(pinacol)diborane / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

4.2: 2.5 h / 90 °C / Inert atmosphere

5.1: sodium hydroxide; water / methanol / 1 h / 65 °C

5.2: 1.5 h / 50 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h

6.2: 0.33 h

6.3: 20 h

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; isopropylmagnesium chloride; potassium acetate; potassium carbonate; bis(pinacol)diborane; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;