Technology Process of DL-2-benzamido-4-(3-pyridyl)butyric acid
There total 4 articles about DL-2-benzamido-4-(3-pyridyl)butyric acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N,N,N',N'-tetramethylguanidine;
In
N,N-dimethyl-formamide;
for 48h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 27 percent / lead tetra-acetate / pyridine / 16 h / Ambient temperature
2: 17 g / ammonium chloride / diethyl ether; H2O / 1.) 0 deg C, 4 h; 2.) 50 deg C, 7.5 h
3: 12M aq. hydrochloric acid / 1.) 64 h, room temperature; 2.) 30 h, reflux temperature
4: 91 percent / 1,1,3,3-tetramethylguanidine / dimethylformamide / 48 h / Ambient temperature
With
lead(IV) acetate; hydrogenchloride; ammonium chloride; N,N,N',N'-tetramethylguanidine;
In
pyridine; diethyl ether; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 17 g / ammonium chloride / diethyl ether; H2O / 1.) 0 deg C, 4 h; 2.) 50 deg C, 7.5 h
2: 12M aq. hydrochloric acid / 1.) 64 h, room temperature; 2.) 30 h, reflux temperature
3: 91 percent / 1,1,3,3-tetramethylguanidine / dimethylformamide / 48 h / Ambient temperature
With
hydrogenchloride; ammonium chloride; N,N,N',N'-tetramethylguanidine;
In
diethyl ether; water; N,N-dimethyl-formamide;