L-2-benzamido-4-(3-pyridyl)butyric acid

Base Information Edit

Chemical Name:L-2-benzamido-4-(3-pyridyl)butyric acid
CAS No.:99528-72-0
Molecular Formula:C₁₆H₁₆N₂O₃
Molecular Weight:284.315
Hs Code.:
Mol file:99528-72-0.mol

Synonyms:L-2-benzamido-4-(3-pyridyl)butyric acid

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Chemical Property of L-2-benzamido-4-(3-pyridyl)butyric acid Edit

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Technology Process of L-2-benzamido-4-(3-pyridyl)butyric acid

There total 6 articles about L-2-benzamido-4-(3-pyridyl)butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 99461-43-5
methyl DL-2-benzamido-4-(3-pyridyl)butyrate

: 99528-71-9
methyl D-2-benzamido-4-(3-pyridyl)butyrate

: 99528-72-0
L-2-benzamido-4-(3-pyridyl)butyric acid

Guidance literature:: In methanol; at 37 ℃; for 3h; α-chymotrypsin, 0.2M-ammonium acetate buffer at pH 7.8;

Reference yield:

: 2859-67-8
3-(3-pyridyl)propan-1-ol

: 99528-72-0
L-2-benzamido-4-(3-pyridyl)butyric acid

Guidance literature:: Multi-step reaction with 6 steps

1: 27 percent / lead tetra-acetate / pyridine / 16 h / Ambient temperature

2: 17 g / ammonium chloride / diethyl ether; H₂O / 1.) 0 deg C, 4 h; 2.) 50 deg C, 7.5 h

3: 12M aq. hydrochloric acid / 1.) 64 h, room temperature; 2.) 30 h, reflux temperature

4: 91 percent / 1,1,3,3-tetramethylguanidine / dimethylformamide / 48 h / Ambient temperature

5: 97 percent / thionyl chloride / 1.) -10 deg C, 20 min; 2.) allowed to warm, 1 h

6: 94 percent / methanol / 3 h / 37 °C / α-chymotrypsin, 0.2M-ammonium acetate buffer at pH 7.8

With lead(IV) acetate; hydrogenchloride; thionyl chloride; ammonium chloride; N,N,N',N'-tetramethylguanidine; In pyridine; methanol; diethyl ether; water; N,N-dimethyl-formamide;

Reference yield:

: 1802-16-0
3-(3-pyridinyl)propionaldehyde

: 99528-72-0
L-2-benzamido-4-(3-pyridyl)butyric acid

Guidance literature:: Multi-step reaction with 5 steps

1: 17 g / ammonium chloride / diethyl ether; H₂O / 1.) 0 deg C, 4 h; 2.) 50 deg C, 7.5 h

2: 12M aq. hydrochloric acid / 1.) 64 h, room temperature; 2.) 30 h, reflux temperature

3: 91 percent / 1,1,3,3-tetramethylguanidine / dimethylformamide / 48 h / Ambient temperature

4: 97 percent / thionyl chloride / 1.) -10 deg C, 20 min; 2.) allowed to warm, 1 h

5: 94 percent / methanol / 3 h / 37 °C / α-chymotrypsin, 0.2M-ammonium acetate buffer at pH 7.8

With hydrogenchloride; thionyl chloride; ammonium chloride; N,N,N',N'-tetramethylguanidine; In methanol; diethyl ether; water; N,N-dimethyl-formamide;