7-((4-(4-fluorophenyl)piperazin-1-yl)methyl)-4-isopropyl-2H-benzo[b][1,4]oxazin-3(4H)-one

Base Information

Chemical Name:7-((4-(4-fluorophenyl)piperazin-1-yl)methyl)-4-isopropyl-2H-benzo[b][1,4]oxazin-3(4H)-one
CAS No.:1580053-40-2
Molecular Formula:C₂₂H₂₆FN₃O₂
Molecular Weight:383.466
Hs Code.:

Synonyms:7-((4-(4-fluorophenyl)piperazin-1-yl)methyl)-4-isopropyl-2H-benzo[b][1,4]oxazin-3(4H)-one

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Chemical Property of 7-((4-(4-fluorophenyl)piperazin-1-yl)methyl)-4-isopropyl-2H-benzo[b][1,4]oxazin-3(4H)-one

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Technology Process of 7-((4-(4-fluorophenyl)piperazin-1-yl)methyl)-4-isopropyl-2H-benzo[b][1,4]oxazin-3(4H)-one

There total 5 articles about 7-((4-(4-fluorophenyl)piperazin-1-yl)methyl)-4-isopropyl-2H-benzo[b][1,4]oxazin-3(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1580053-63-9
C₂₂H₂₇BrFN₃O₂

: 1580053-40-2
7-((4-(4-fluorophenyl)piperazin-1-yl)methyl)-4-isopropyl-2H-benzo[b][1,4]oxazin-3(4H)-one

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 120 ℃;
DOI:10.1016/j.bmcl.2014.02.014

Reference yield:

: 2973-78-6
3-bromo-4-hydroxybenzylaldehyde

: 1580053-40-2
7-((4-(4-fluorophenyl)piperazin-1-yl)methyl)-4-isopropyl-2H-benzo[b][1,4]oxazin-3(4H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate / ethanol / 0 - 5 °C

2: phosphorus tribromide / dichloromethane / 20 °C / Cooling with ice

3: potassium carbonate / acetonitrile / 20 °C

4: potassium carbonate / acetonitrile / Reflux

5: caesium carbonate / N,N-dimethyl-formamide / 120 °C

With sodium tetrahydroborate; phosphorus tribromide; potassium carbonate; caesium carbonate; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 4: |Williamson Ether Synthesis / 5: |Smiles Aromatic Rearrangement;
DOI:10.1016/j.bmcl.2014.02.014

Reference yield:

: 29922-56-3
2-bromo-4-(hydroxymethyl)phenol

: 1580053-40-2
7-((4-(4-fluorophenyl)piperazin-1-yl)methyl)-4-isopropyl-2H-benzo[b][1,4]oxazin-3(4H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: phosphorus tribromide / dichloromethane / 20 °C / Cooling with ice

2: potassium carbonate / acetonitrile / 20 °C

3: potassium carbonate / acetonitrile / Reflux

4: caesium carbonate / N,N-dimethyl-formamide / 120 °C

With phosphorus tribromide; potassium carbonate; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; 3: |Williamson Ether Synthesis / 4: |Smiles Aromatic Rearrangement;
DOI:10.1016/j.bmcl.2014.02.014