Technology Process of 4-(2,5-Dimethoxy-phenyl)-4-methyl-cyclohexane-1,3-dione
There total 4 articles about 4-(2,5-Dimethoxy-phenyl)-4-methyl-cyclohexane-1,3-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 63 percent / Jones reagent / acetone / 1 h / 0 °C
2: 84 percent / NaH / tetrahydrofuran / 1.) 0 deg C to room temperature, 30 min, 2.) 0 deg C, 1 h; room temperature, 4 h
3: 626 mg / t-BuOK / tetrahydrofuran / 1.) 30 min, 2.) 3 d
With
jones reagent; potassium tert-butylate; sodium hydride;
In
tetrahydrofuran; acetone;
DOI:10.1021/jo970570q
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 84 percent / NaH / tetrahydrofuran / 1.) 0 deg C to room temperature, 30 min, 2.) 0 deg C, 1 h; room temperature, 4 h
2: 626 mg / t-BuOK / tetrahydrofuran / 1.) 30 min, 2.) 3 d
With
potassium tert-butylate; sodium hydride;
In
tetrahydrofuran;
DOI:10.1021/jo970570q
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 58 percent / n-BuLi, TMEDA / diethyl ether; hexane / 1.) room temperature, 6 h, 2.) room temperature, 8 h
2: 63 percent / Jones reagent / acetone / 1 h / 0 °C
3: 84 percent / NaH / tetrahydrofuran / 1.) 0 deg C to room temperature, 30 min, 2.) 0 deg C, 1 h; room temperature, 4 h
4: 626 mg / t-BuOK / tetrahydrofuran / 1.) 30 min, 2.) 3 d
With
n-butyllithium; jones reagent; N,N,N,N,-tetramethylethylenediamine; potassium tert-butylate; sodium hydride;
In
tetrahydrofuran; diethyl ether; hexane; acetone;
DOI:10.1021/jo970570q
