Hydroxy-(4-methoxy-2,6-dimethyl-phenyl)-acetic acid methyl ester

Base Information

• Chemical Name: Hydroxy-(4-methoxy-2,6-dimethyl-phenyl)-acetic acid methyl ester
• CAS No.: 92516-16-0
• Molecular Formula: C₁₂H₁₆O₄
• Molecular Weight: 224.257
• Mol file: 92516-16-0.mol

Synonyms:Hydroxy-(4-methoxy-2,6-dimethyl-phenyl)-acetic acid methyl ester

Chemical Property of Hydroxy-(4-methoxy-2,6-dimethyl-phenyl)-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Hydroxy-(4-methoxy-2,6-dimethyl-phenyl)-acetic acid methyl ester

There total 3 articles about Hydroxy-(4-methoxy-2,6-dimethyl-phenyl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxy-2,6-dimethylbenzylaldehyde (19447-00-8) → Hydroxy-(4-methoxy-2,6-dimethyl-phenyl)-acetic acid methyl ester (92516-16-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / CaO / 2 h / 50 °C

2: 76 percent / HCl(g) / ethanol / 3 h / 50 °C

3: 1.) 30percent aq KOH

With hydrogenchloride; potassium hydroxide; calcium oxide; In ethanol;

DOI:10.1246/bcsj.57.1510

Reference yield:

Cyanhydrin von 2.6-Dimethyl-4-methoxybenzaldehyd (70242-29-4) → Hydroxy-(4-methoxy-2,6-dimethyl-phenyl)-acetic acid methyl ester (92516-16-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / HCl(g) / ethanol / 3 h / 50 °C

2: 1.) 30percent aq KOH

With hydrogenchloride; potassium hydroxide; In ethanol;

DOI:10.1246/bcsj.57.1510

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2-Hydroxy-2-(4-methoxy-2,6-dimethyl-phenyl)-acetamide (92516-15-9) → Hydroxy-(4-methoxy-2,6-dimethyl-phenyl)-acetic acid methyl ester (92516-16-0)

Guidance literature:

With potassium hydroxide; Yield given. Multistep reaction;

DOI:10.1246/bcsj.57.1510

upstream raw materials:

diazomethane

2-Hydroxy-2-(4-methoxy-2,6-dimethyl-phenyl)-acetamide

4-methoxy-2,6-dimethylbenzylaldehyde

Cyanhydrin von 2.6-Dimethyl-4-methoxybenzaldehyd

Downstream raw materials:

Ethoxy-(4-methoxy-2,6-dimethyl-phenyl)-acetic acid methyl ester

2,4-dinitrophenylhydrazone of methyl glyoxylate

1,3-dibromo-6-methoxy-2,4-dimethylbenzene

Acetoxy-(4-methoxy-2,6-dimethyl-phenyl)-acetic acid methyl ester