19447-00-8

Basic information

• Product Name: 4-METHOXY-2,6-DIMETHYLBENZALDEHYDE
• Synonyms: 4-METHOXY-2,6-DIMETHYLBENZALDEHYDE
• CAS NO: 19447-00-8
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.2
• Mol File: 19447-00-8.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-METHOXY-2,6-DIMETHYLBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXY-2,6-DIMETHYLBENZALDEHYDE(19447-00-8)
• EPA Substance Registry System: 4-METHOXY-2,6-DIMETHYLBENZALDEHYDE(19447-00-8)

Safety Data

• Hazardous Substances Data: 19447-00-8(Hazardous Substances Data)

Usage

General Description

4-Methoxy-2,6-dimethylbenzaldehyde is a chemical compound commonly used as a fragrance ingredient in perfumes and personal care products. It is a pale yellow liquid with a strong sweet, floral odor, and is synthesized through a multi-step process starting from 4-methoxytoluene. 4-METHOXY-2,6-DIMETHYLBENZALDEHYDE is a versatile building block in organic synthesis and is used as a flavor and fragrance agent. It is also a key ingredient in the production of various industrial and household products, including fragrances, deodorants, and air fresheners. Additionally, 4-methoxy-2,6-dimethylbenzaldehyde is utilized in the synthesis of pharmaceuticals and agrochemicals due to its unique properties and reactivity.

Upstream product

• 2591-86-8 N-Formylpiperidine 
• 90609-47-5 1-iodo-2,6-dimethyl-4-methoxybenzene 
• 4885-02-3 Dichloromethyl methyl ether 
• 874-63-5 3,5-dimethylmethoxybenzene 
• 1634-04-4 tert-butyl methyl ether 
• 6267-34-1 2-bromo-5-methoxy-1,3-dimethyl-benzene 
• 594-19-4 tert.-butyl lithium 
• 108-68-9 3,5-Dimethylphenol 
• 557-21-1 dicyanozinc 
• 68-12-2 N,N-dimethyl-formamide 
• 70547-87-4 2,6-dimethyl-4-hydroxybenzaldehyde 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 74-90-8 hydrogen cyanide 

Downstream Products

• 21573-41-1 3,4,5-Trimethylanisole 
• 61019-03-2 5-methoxy-1,3-dimethyl-2-nitrobenzene 
• 37934-89-7 2,6-Dimethyl-4-methoxybenzoic acid 
• 38718-66-0 5-methoxy-benzene-1,2,3-tricarboxylic acid trimethyl ester 
• 19447-02-0 1-(2,6-dimethyl-4-methoxyphenyl)ethanol 
• 161869-50-7 (2E)-ethyl-3-(4'-methoxy-2',6'-dimethylphenyl)-2-propenoate 
• 259732-28-0 8-(4-methoxy-2,6-dimethylbenzylamino)-2,3-dimethylimidazo[1,2-a]pyridine 
• 1079354-14-5 5-(1-methylethyl)-2-(4-methoxy-2,6-dimethylphenyl)-3,7-dimethylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one 
• 1079355-01-3 5-(1-methylpropyl)-2-(4-methoxy-2,6-dimethylphenyl)-3,7-dimethylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one 
• 1354228-09-3 2,2,2-trifluoro-1-(2,6-dimethyl-4-methoxyphenyl)ethyl trimethylsilyl ether 
• 1354228-21-9 2,2,2-trifluoro-1-(2,6-dimethyl-4-methoxyphenyl)ethanol 
• 211110-65-5 3,5-dimethyl-4-(3'-isopropyl-4'-methoxybenzylhydroxy) anisole 

Relevant articles and documents

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The synthesis of angularly fused quinone natural products has been achieved using a photoenolization reaction and a Diels-Alder reaction in the key carbon-carbon bond forming steps.

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Here the aromatic formylation mediated by TiCl4 and dichloromethyl methyl ether previously described by our group has been explored for a wide range of aromatic rings, including phenols, methoxy- and methylbenzenes, as an excellent way to produce aromatic aldehydes. Here we determine that the regioselectivity of this process is highly promoted by the coordination between the atoms present in the aromatic moiety and those in the metal core.

Acid-labile cys-protecting groups for the Fmoc/tBu strategy: Filling the gap

To address the existing gap in the current set of acid-labile Cys-protecting groups for the Fmoc/tBu strategy, diverse Fmoc-Cys(PG)-OH derivatives were prepared and incorporated into a model tripeptide to study their stability against TFA. S-Dpm proved to be compatible with the commonly used S-Trt group and was applied for the regioselecive construction of disulfide bonds.

Synthesis of novel structurally simplified estrogen analogues with electron-donating groups in ring A

A library of 25 novel estrogen analogues were prepared in five to eight steps from mostly commercially available substituted anisoles via bromination, formylation, Corey-Fuchs reaction, elimination, and Sonogashira reaction. Georg Thieme Verlag Stuttgart.