4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester
CAS No.:1053656-57-7
Molecular Formula:C12H16ClN3O2
Molecular Weight:269.731
Hs Code.:2933990090
Mol file:1053656-57-7.mol

Synonyms:4-Chloro-5,8-Dihydro-Pyrido[3,4-D]Pyrimidine-7(6H)-Carboxylic Acid Tert-Butyl Ester

Suppliers and Price of 4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
tert-Butyl4-Chloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8h)-carboxylate
10mg
$ 45.00

SynQuest Laboratories
tert-Butyl 4-chloro-5H,6H,8H-pyrido[3,4-d]pyrimidine-7-carboxylate
250 mg
$ 265.00

SynQuest Laboratories
tert-Butyl 4-chloro-5H,6H,8H-pyrido[3,4-d]pyrimidine-7-carboxylate
1 g
$ 825.00

SynChem
TERT-BUTYL 4-CHLORO-5,6-DIHYDROPYRIDO[3,4-D]PYRIMIDINE-7(8H)-CARBOXYLATE 95%
1 g
$ 560.00

Matrix Scientific
tert-Butyl 4-chloro-5,6-dihydropyrido-[3,4-d]pyrimidine-7(8H)-carboxylate 95+%
1g
$ 915.00

Matrix Scientific
tert-Butyl 4-chloro-5,6-dihydropyrido-[3,4-d]pyrimidine-7(8H)-carboxylate 95+%
250mg
$ 370.00

Crysdot
tert-Butyl4-chloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate 95+%
1g
$ 344.00

Chemcia Scientific
4-Chloro-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylicacidtert-butylester 95%
2.5 G
$ 850.00

Ambeed
tert-Butyl4-chloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate 95%
1g
$ 337.00

Ambeed
tert-Butyl4-chloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate 95%
250mg
$ 120.00

Total 30 raw suppliers

Chemical Property of 4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester

Chemical Property:

Boiling Point:395.8±42.0 °C(Predicted)
PKA:-0.04±0.20(Predicted)
PSA：55.32000
Density:1.266±0.06 g/cm3(Predicted)
LogP:2.36110

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl4-Chloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8h)-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester

There total 8 articles about 4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1142188-60-0
4-hydroxy-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester

: 1053656-57-7
4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester

Guidance literature:: With tetrachloromethane; triphenylphosphine; In 1,2-dichloro-ethane; at 70 ℃; for 2.5h; Inert atmosphere;

Reference yield:

: 1142188-60-0
4-oxo-4,5,6,8-tetrahydro-3H-pyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester

: 1053656-57-7
4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester

Guidance literature:: With tetrachloromethane; triphenylphosphine; In 1,2-dichloro-ethane; at 70 ℃; for 2.5h;

Reference yield:

: 39514-19-7
ethyl 1-benzyl-3-oxo-4-piperidinecarboxylate

: 1053656-57-7
4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h

1.2: 16 h / 20 °C

2.1: sodium ethanolate / ethanol / 5 h / 70 °C

3.1: triphenylphosphine / 1,2-dichloro-ethane

3.2: 2.5 h / 70 °C

With hydrogen; sodium ethanolate; triphenylphosphine; palladium 10% on activated carbon; In ethanol; 1,2-dichloro-ethane;