ethyl 7-(4-chlorobenzenesulfonylamino)-6-ethoxythiocarbonylsulfanyl-3-oxoheptanoate

Base Information

• Chemical Name: ethyl 7-(4-chlorobenzenesulfonylamino)-6-ethoxythiocarbonylsulfanyl-3-oxoheptanoate
• CAS No.: 946076-64-8
• Molecular Formula: C₁₈H₂₄ClNO₆S₃
• Molecular Weight: 482.043
• Mol file: 946076-64-8.mol

Synonyms:ethyl 7-(4-chlorobenzenesulfonylamino)-6-ethoxythiocarbonylsulfanyl-3-oxoheptanoate

Chemical Property of ethyl 7-(4-chlorobenzenesulfonylamino)-6-ethoxythiocarbonylsulfanyl-3-oxoheptanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 7-(4-chlorobenzenesulfonylamino)-6-ethoxythiocarbonylsulfanyl-3-oxoheptanoate

There total 1 articles about ethyl 7-(4-chlorobenzenesulfonylamino)-6-ethoxythiocarbonylsulfanyl-3-oxoheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

N-allyl-4-chlorobenzenesulfonamide (830-42-2) + ethyl 4-((ethoxycarbonothioyl)thio)-3-oxobutanoate (58933-02-1) → ethyl 7-(4-chlorobenzenesulfonylamino)-6-ethoxythiocarbonylsulfanyl-3-oxoheptanoate (946076-64-8)

Guidance literature:

With dilauryl peroxide; In 1,2-dichloro-ethane; Heating;

DOI:10.1016/j.tet.2007.04.091

Reference yield: 75.0%

ethyl 7-(4-chlorobenzenesulfonylamino)-6-ethoxythiocarbonylsulfanyl-3-oxoheptanoate (946076-64-8) + acetyl chloride (75-36-5) → ethyl 7-(N-acetyl-N-(4-chlorobenzenesulfonyl)amino)-6-ethoxythiocarbonylsulfanyl-3-oxoheptanoate (946076-37-5)

Guidance literature:

With dmap; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1016/j.tet.2007.04.091

Reference yield:

ethyl 7-(4-chlorobenzenesulfonylamino)-6-ethoxythiocarbonylsulfanyl-3-oxoheptanoate (946076-64-8) → ethyl 7-acetylamino-6-(4-chlorophenyl)-3-oxoheptanoate

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / DMAP / CH₂Cl₂ / 2 h / 0 - 20 °C

2: 60 percent / lauroyl peroxide / propan-2-ol / Heating

With dmap; dilauryl peroxide; In dichloromethane; isopropyl alcohol;

DOI:10.1016/j.tet.2007.04.091

upstream raw materials:

N-allyl-4-chlorobenzenesulfonamide

ethyl 4-((ethoxycarbonothioyl)thio)-3-oxobutanoate

Downstream raw materials:

ethyl 7-(N-acetyl-N-(4-chlorobenzenesulfonyl)amino)-6-ethoxythiocarbonylsulfanyl-3-oxoheptanoate