4-methyl ether of 2,3-dimethoxy-5-methylhydroquinone

Base Information

• Chemical Name: 4-methyl ether of 2,3-dimethoxy-5-methylhydroquinone
• CAS No.: 39727-82-7
• Molecular Formula: C₁₀H₁₄O₄
• Molecular Weight: 198.219
• Mol file: 39727-82-7.mol

Synonyms:4-methyl ether of 2,3-dimethoxy-5-methylhydroquinone

Chemical Property of 4-methyl ether of 2,3-dimethoxy-5-methylhydroquinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-methyl ether of 2,3-dimethoxy-5-methylhydroquinone

There total 6 articles about 4-methyl ether of 2,3-dimethoxy-5-methylhydroquinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2,3,4,4-tetramethoxycyclohexa-2,5-dien-1-one + dimethyl zinc(II) (544-97-8) → 4-methyl ether of 2,3-dimethoxy-5-methylhydroquinone (39727-82-7) + (S)-2,3,4,4-tetramethoxy-5-methylcyclohex-2-en-1-one

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); (3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-(1-phenyl-ethyl)-amine; In toluene; at -5 ℃; Temperature; enantioselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201600542

Reference yield: 42.9%

2,3-dimethoxy-5-methylbenzene-1,4-diol (3066-90-8) + dimethyl sulfate (77-78-1) → 4-methyl ether of 2,3-dimethoxy-5-methylhydroquinone (39727-82-7) + 2,3,4-trimethoxy-6-methylphenol (39068-88-7)

Guidance literature:

With potassium carbonate; In acetone; for 1.5h; Heating;

Reference yield: 23.0%

2,3-dimethoxy-5-methylbenzene-1,4-diol (3066-90-8) + methyl iodide (74-88-4) → 4-methyl ether of 2,3-dimethoxy-5-methylhydroquinone (39727-82-7) + 2,3,4-trimethoxy-6-methylphenol (39068-88-7)

Guidance literature:

2,3-dimethoxy-5-methylbenzene-1,4-diol; With caesium carbonate; In acetone; at 60 ℃; Inert atmosphere;

methyl iodide; In acetone; for 3h; Reflux;

With hydrogenchloride; In water;

DOI:10.1021/jo8016555

upstream raw materials:

2,3-dimethoxy-5-methylbenzene-1,4-diol

dimethyl sulfate

1,2,3-trimethoxy-4-methylbenzene

2,3,4-trimethoxybenzaldehyde

Downstream raw materials:

2,3-Dimethoxy-5-methyl-1,4-benzoquinone