4-((5-(2-(4-(5-cyano-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)oxy)benzenesulfonamide

Base Information

Chemical Name:4-((5-(2-(4-(5-cyano-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)oxy)benzenesulfonamide
CAS No.:1613053-94-3
Molecular Formula:C₂₉H₂₇N₇O₄S
Molecular Weight:569.644
Hs Code.:

Synonyms:4-((5-(2-(4-(5-cyano-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)oxy)benzenesulfonamide

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Chemical Property of 4-((5-(2-(4-(5-cyano-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)oxy)benzenesulfonamide

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Technology Process of 4-((5-(2-(4-(5-cyano-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)oxy)benzenesulfonamide

There total 9 articles about 4-((5-(2-(4-(5-cyano-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)oxy)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1576-43-8
4-hydroxybenzenesulphonamide

: 1613053-83-0
2-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-1H-benzo[d]imidazole-5-carbonitrile

: 1613053-94-3
4-((5-(2-(4-(5-cyano-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)oxy)benzenesulfonamide

Guidance literature:: 4-hydroxybenzenesulphonamide; With caesium carbonate; In dimethyl sulfoxide; at 20 ℃; for 0.5h;

2-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-1H-benzo[d]imidazole-5-carbonitrile; In dimethyl sulfoxide; at 120 ℃;
DOI:10.1021/ml5001728

Reference yield: 24.0%

: 1576-43-8
4-hydroxybenzenesulphonamide

: 1613053-81-8
7-fluoro-1-(2-(4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)ethyl)-1,5-naphthyridin-2(1H)-one

: 1613053-94-3
4-((5-(2-(4-(5-cyano-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)oxy)benzenesulfonamide

Guidance literature:: 4-hydroxybenzenesulphonamide; With caesium carbonate; In dimethyl sulfoxide; at 20 ℃; for 0.5h;

7-fluoro-1-(2-(4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)ethyl)-1,5-naphthyridin-2(1H)-one; In dimethyl sulfoxide; at 120 ℃;
DOI:10.1021/ml5001728

Reference yield:

: 884495-03-8
3-amino-2-bromo-5-fluoropyridine

: 1613053-94-3
4-((5-(2-(4-(5-cyano-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)oxy)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium diacetate; tri-tert-butyl phosphine; N-Methyldicyclohexylamine; Isopropylbenzene / 150 °C

2.1: caesium carbonate / dimethyl sulfoxide / 0.17 h / 20 °C

2.2: 20 - 90 °C

3.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4.1: sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C

5.1: caesium carbonate / dimethyl sulfoxide / 0.5 h / 20 °C

5.2: 120 °C

With Isopropylbenzene; tri-tert-butyl phosphine; N-Methyldicyclohexylamine; palladium diacetate; sodium carbonate; caesium carbonate; triethylamine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ml5001728