2-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-1H-benzo[d]imidazole-5-carbonitrile

Base Information

Chemical Name:2-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-1H-benzo[d]imidazole-5-carbonitrile
CAS No.:1613053-83-0
Molecular Formula:C₂₃H₂₁FN₆O
Molecular Weight:416.458
Hs Code.:

Synonyms:2-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-1H-benzo[d]imidazole-5-carbonitrile

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Chemical Property of 2-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-1H-benzo[d]imidazole-5-carbonitrile

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Technology Process of 2-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-1H-benzo[d]imidazole-5-carbonitrile

There total 1 articles about 2-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-1H-benzo[d]imidazole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 884495-03-8
3-amino-2-bromo-5-fluoropyridine

: 1613053-83-0
2-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-1H-benzo[d]imidazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium diacetate; tri-tert-butyl phosphine; N-Methyldicyclohexylamine; Isopropylbenzene / 150 °C

2.1: caesium carbonate / dimethyl sulfoxide / 0.17 h / 20 °C

2.2: 20 - 90 °C

3.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4.1: sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C

With Isopropylbenzene; tri-tert-butyl phosphine; N-Methyldicyclohexylamine; palladium diacetate; sodium carbonate; caesium carbonate; triethylamine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ml5001728

Reference yield: 29.0%

: 1576-43-8
4-hydroxybenzenesulphonamide

: 1613053-83-0
2-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-1H-benzo[d]imidazole-5-carbonitrile

: 1613053-94-3
4-((5-(2-(4-(5-cyano-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)oxy)benzenesulfonamide

Guidance literature:: 4-hydroxybenzenesulphonamide; With caesium carbonate; In dimethyl sulfoxide; at 20 ℃; for 0.5h;

2-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-1H-benzo[d]imidazole-5-carbonitrile; In dimethyl sulfoxide; at 120 ℃;
DOI:10.1021/ml5001728