(2R,4S,6S)-2-(2-oxo-2-phenylethyl)-6-phenyltetrahydro-2H-pyran-4-yl-4-nitrobenzoate

Base Information

Chemical Name:(2R,4S,6S)-2-(2-oxo-2-phenylethyl)-6-phenyltetrahydro-2H-pyran-4-yl-4-nitrobenzoate
CAS No.:956035-54-4
Molecular Formula:C₂₆H₂₃NO₆
Molecular Weight:445.472
Hs Code.:

Synonyms:(2R,4S,6S)-2-(2-oxo-2-phenylethyl)-6-phenyltetrahydro-2H-pyran-4-yl-4-nitrobenzoate

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Chemical Property of (2R,4S,6S)-2-(2-oxo-2-phenylethyl)-6-phenyltetrahydro-2H-pyran-4-yl-4-nitrobenzoate

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Technology Process of (2R,4S,6S)-2-(2-oxo-2-phenylethyl)-6-phenyltetrahydro-2H-pyran-4-yl-4-nitrobenzoate

There total 3 articles about (2R,4S,6S)-2-(2-oxo-2-phenylethyl)-6-phenyltetrahydro-2H-pyran-4-yl-4-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 956035-52-2
(2S,4S,6R)-2-phenyl-6-[(E)-styryl]tetrahydro-2H-pyran-4-yl-4-nitrobenzoate

: 956035-54-4
(2R,4S,6S)-2-(2-oxo-2-phenylethyl)-6-phenyltetrahydro-2H-pyran-4-yl-4-nitrobenzoate

Guidance literature:: With oxygen; copper(l) chloride; palladium dichloride; In water; N,N-dimethyl-formamide; at 50 - 55 ℃; for 72h;
DOI:10.1055/s-2007-984886

Reference yield:

: 951325-91-0
(2S,4R,6R,E)-2-phenyl-6-styryltetrahydro-2H-pyran-4-ol

: 956035-54-4
(2R,4S,6S)-2-(2-oxo-2-phenylethyl)-6-phenyltetrahydro-2H-pyran-4-yl-4-nitrobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / PPh₃; DIAD / toluene / 3 h / 20 °C

2: 89 percent / CuCl; O₂ / PdCl₂ / dimethylformamide; H₂O / 72 h / 50 - 55 °C

With di-isopropyl azodicarboxylate; oxygen; triphenylphosphine; copper(l) chloride; palladium dichloride; In water; N,N-dimethyl-formamide; toluene; 1: Mitsunobu reaction / 2: Wacker oxidation;
DOI:10.1055/s-2007-984886

Reference yield:

: 956035-49-7
(2S,4R,6R)-2-phenyl-6-[(E)-styryl]tetrahydro-2H-pyran-4-yl acetate

: 956035-54-4
(2R,4S,6S)-2-(2-oxo-2-phenylethyl)-6-phenyltetrahydro-2H-pyran-4-yl-4-nitrobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / methanol / 0.25 h / 20 °C

2: 90 percent / PPh₃; DIAD / toluene / 3 h / 20 °C

3: 89 percent / CuCl; O₂ / PdCl₂ / dimethylformamide; H₂O / 72 h / 50 - 55 °C

With di-isopropyl azodicarboxylate; oxygen; potassium carbonate; triphenylphosphine; copper(l) chloride; palladium dichloride; In methanol; water; N,N-dimethyl-formamide; toluene; 2: Mitsunobu reaction / 3: Wacker oxidation;
DOI:10.1055/s-2007-984886