4-fluoro-N-benzylanthranilic acid

Base Information

• Chemical Name: 4-fluoro-N-benzylanthranilic acid
• CAS No.: 1002965-92-5
• Molecular Formula: C₁₄H₁₂FNO₂
• Molecular Weight: 245.253
• Mol file: 1002965-92-5.mol

Synonyms:4-fluoro-N-benzylanthranilic acid

Chemical Property of 4-fluoro-N-benzylanthranilic acid

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-fluoro-N-benzylanthranilic acid

There total 2 articles about 4-fluoro-N-benzylanthranilic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-choro-4-fluorobenzoic acid (2252-51-9) + benzylamine (100-46-9) → 4-fluoro-N-benzylanthranilic acid (1002965-92-5)

Guidance literature:

With copper(I) oxide; copper; potassium carbonate; In various solvent(s); at 130 ℃; for 24h;

DOI:10.1055/s-2007-990875

Reference yield: 90.0%

2-bromo-4-fluorobenzoic acid (1006-41-3) + benzylamine (100-46-9) → 4-fluoro-N-benzylanthranilic acid (1002965-92-5)

Guidance literature:

With copper(I) oxide; copper; potassium carbonate; In various solvent(s); at 130 ℃; for 24h;

DOI:10.1055/s-2007-990875

Reference yield: 66.0%

4-fluoro-N-benzylanthranilic acid (1002965-92-5) + N-ethyl-N-[2-(7-chloro-4-quinolyl)aminoethyl]-1,2-diaminoethane (1108999-74-1) → N-[2-{N'-2-(7-chloro-4-quinolyl)aminoethyl-N''-ethyl}aminoethyl]-2-benzylamino-4-fluorobenzamide (1109000-33-0)

Guidance literature:

4-fluoro-N-benzylanthranilic acid; With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In chloroform; at 0 - 20 ℃;

N-ethyl-N-[2-(7-chloro-4-quinolyl)aminoethyl]-1,2-diaminoethane; In chloroform; N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2008.11.009

upstream raw materials:

2-choro-4-fluorobenzoic acid

benzylamine

2-bromo-4-fluorobenzoic acid

Downstream raw materials:

N-[2-{N'-2-(7-chloro-4-quinolyl)aminoethyl-N''-ethyl}aminoethyl]-2-benzylamino-4-fluorobenzamide

N-(7-chloro-4-quinolyl)-N'-(2-benzylamino-4-fluorobenzoyl)-1,3-diaminopropane

Refernces