2-phenylpropynoic acid [3-(2-bromo-4,5-dimethoxyphenyl)propyl]-(4-methoxybenzyl)amide

Base Information

Chemical Name:2-phenylpropynoic acid [3-(2-bromo-4,5-dimethoxyphenyl)propyl]-(4-methoxybenzyl)amide
CAS No.:947530-72-5
Molecular Formula:C₂₈H₂₈BrNO₄
Molecular Weight:522.439
Hs Code.:

Synonyms:2-phenylpropynoic acid [3-(2-bromo-4,5-dimethoxyphenyl)propyl]-(4-methoxybenzyl)amide

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Chemical Property of 2-phenylpropynoic acid [3-(2-bromo-4,5-dimethoxyphenyl)propyl]-(4-methoxybenzyl)amide

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Technology Process of 2-phenylpropynoic acid [3-(2-bromo-4,5-dimethoxyphenyl)propyl]-(4-methoxybenzyl)amide

There total 5 articles about 2-phenylpropynoic acid [3-(2-bromo-4,5-dimethoxyphenyl)propyl]-(4-methoxybenzyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(2-bromo-4,5-dimethoxyphenyl)-N-(4-methoxybenzyl)acrylamide

: 947530-72-5
2-phenylpropynoic acid [3-(2-bromo-4,5-dimethoxyphenyl)propyl]-(4-methoxybenzyl)amide

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / TsNHNH₂; aq. AcONa / 1,2-dimethoxy-ethane / 2 h / Heating

2: 86 percent / BF₃*THF / tetrahydrofuran / Heating

3: 98 percent / dioxane / 20 °C

With boron trifluoride-tetrahydrofuran complex; sodium acetate; toluene-4-sulfonic acid hydrazide; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane;
DOI:10.1021/ol071079g

Reference yield:

: 947530-54-3
3-(2-bromo-4,5-dimethoxyphenyl)-N-(4-methoxybenzyl)propionamide

: 947530-72-5
2-phenylpropynoic acid [3-(2-bromo-4,5-dimethoxyphenyl)propyl]-(4-methoxybenzyl)amide

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / BF₃*THF / tetrahydrofuran / Heating

2: 98 percent / dioxane / 20 °C

With boron trifluoride-tetrahydrofuran complex; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/ol071079g

Reference yield:

: 151539-52-5
2-bromo-4,5-dimethoxycinnamic acid

: 947530-72-5
2-phenylpropynoic acid [3-(2-bromo-4,5-dimethoxyphenyl)propyl]-(4-methoxybenzyl)amide

Guidance literature:: Multi-step reaction with 4 steps

1: DMAP; DCC / CH₂Cl₂ / 20 °C

2: 89 percent / TsNHNH₂; aq. AcONa / 1,2-dimethoxy-ethane / 2 h / Heating

3: 86 percent / BF₃*THF / tetrahydrofuran / Heating

4: 98 percent / dioxane / 20 °C

With dmap; boron trifluoride-tetrahydrofuran complex; sodium acetate; toluene-4-sulfonic acid hydrazide; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/ol071079g