Technology Process of 1,4-bis-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)-ethyl]-9b-hydroxy-7,8-dimethoxy-1,9b-dihydro-3H-benzo[e]indole-2,5-dione
There total 5 articles about 1,4-bis-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)-ethyl]-9b-hydroxy-7,8-dimethoxy-1,9b-dihydro-3H-benzo[e]indole-2,5-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl (3,4-dimethoxyphenyl)acetate;
With
lithium diisopropyl amide;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.5h;
2-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)-ethylamino]-6,7-dimethoxy-[1,4]-naphthoquinone;
With
lithium diisopropyl amide;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
Further stages.;
DOI:10.1021/ol026074s
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 65 percent / sodium hydrogen carbonate / Pd(PPh3)4 / dimethylformamide / 24 h / Heating
2.1: 76 percent / lithium diisopropylamide / tetrahydrofuran; hexane / 3 h / -78 - 20 °C
3.1: 62 percent / hydrogen peroxide; iodine; sulfuric acid / methanol / 4 h / 20 °C
4.1: 80 percent / ethanol / 24 h / 20 °C
5.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.5 h / -78 °C
5.2: 15 percent / lithium diisopropylamide / tetrahydrofuran; hexane / -78 - 20 °C
With
sulfuric acid; dihydrogen peroxide; iodine; sodium hydrogencarbonate; lithium diisopropyl amide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; ethanol; hexane; N,N-dimethyl-formamide;
1.1: Heck reaction;
DOI:10.1021/ol026074s
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 62 percent / hydrogen peroxide; iodine; sulfuric acid / methanol / 4 h / 20 °C
2.1: 80 percent / ethanol / 24 h / 20 °C
3.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.5 h / -78 °C
3.2: 15 percent / lithium diisopropylamide / tetrahydrofuran; hexane / -78 - 20 °C
With
sulfuric acid; dihydrogen peroxide; iodine; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; ethanol; hexane;
DOI:10.1021/ol026074s
