permethyl ningalin C

Base Information

• Chemical Name: permethyl ningalin C
• CAS No.: 322765-98-0
• Molecular Formula: C₄₀H₃₉NO₁₀
• Molecular Weight: 693.75
• Mol file: 322765-98-0.mol

Synonyms:permethyl ningalin C

Chemical Property of permethyl ningalin C

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of permethyl ningalin C

There total 16 articles about permethyl ningalin C which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,4-bis-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)-ethyl]-9b-hydroxy-7,8-dimethoxy-1,9b-dihydro-3H-benzo[e]indole-2,5-dione (457060-14-9) → permethyl ningalin C (322765-98-0)

Guidance literature:

With hydrogenchloride; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1021/ol026074s

Reference yield: 86.0%

4-bromo-3-(3,4-dimethoxyphenethyl)-1-(3,4-dimethoxyphenyl)-7,8-dimethoxy-2H-benzo[e]indole-2,5(3H)-dione + 3,4-Dimethoxyphenylboronic acid (122775-35-3) → permethyl ningalin C (322765-98-0)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃; Sealed tube; Inert atmosphere;

DOI:10.1002/bkcs.11609

Reference yield: 73.0%

methyl (3,4-dimethoxyphenyl)acetate (15964-79-1) + 2-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)-ethylamino]-6,7-dimethoxy-[1,4]-naphthoquinone (457060-08-1) → permethyl ningalin C (322765-98-0) + 1,4-bis-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)-ethyl]-9b-hydroxy-7,8-dimethoxy-1,9b-dihydro-3H-benzo[e]indole-2,5-dione (457060-14-9)

Guidance literature:

methyl (3,4-dimethoxyphenyl)acetate; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

2-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)-ethylamino]-6,7-dimethoxy-[1,4]-naphthoquinone; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 - 20 ℃; Further stages.;

DOI:10.1021/ol026074s

upstream raw materials:

trifluoro-acetic acid 1,4-bis-(3,4-dimethoxy-phenyl)-3-[2-(3,4-dimethoxy-phenyl)-ethyl]-7,8-dimethoxy-3H-benzo[e]indol-5-yl ester

methyl (3,4-dimethoxyphenyl)acetate

2-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)-ethylamino]-6,7-dimethoxy-[1,4]-naphthoquinone

1,4-bis-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)-ethyl]-9b-hydroxy-7,8-dimethoxy-1,9b-dihydro-3H-benzo[e]indole-2,5-dione