2-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)-ethylamino]-6,7-dimethoxy-[1,4]-naphthoquinone

Base Information

• Chemical Name: 2-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)-ethylamino]-6,7-dimethoxy-[1,4]-naphthoquinone
• CAS No.: 457060-08-1
• Molecular Formula: C₃₀H₃₁NO₈
• Molecular Weight: 533.578
• Mol file: 457060-08-1.mol

Synonyms:2-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)-ethylamino]-6,7-dimethoxy-[1,4]-naphthoquinone

Chemical Property of 2-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)-ethylamino]-6,7-dimethoxy-[1,4]-naphthoquinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)-ethylamino]-6,7-dimethoxy-[1,4]-naphthoquinone

There total 8 articles about 2-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)-ethylamino]-6,7-dimethoxy-[1,4]-naphthoquinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) + 2-(3',4'-dimethoxyphenyl)-6,7-dimethoxy-1,4-dihydro-1,4-naphthalenedione (302331-54-0) → 2-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)-ethylamino]-6,7-dimethoxy-[1,4]-naphthoquinone (457060-08-1)

Guidance literature:

In ethanol; at 20 ℃; for 24h;

DOI:10.1021/ol026074s

Reference yield: 57.0%

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) + 2-isopropyloxy-6,7-dimethoxy-3-(3,4-dimethoxyphenyl)-1,4-naphthoquinone (100073-74-3) → 2-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)-ethylamino]-6,7-dimethoxy-[1,4]-naphthoquinone (457060-08-1)

Guidance literature:

In methanol; at 40 ℃; for 16h;

DOI:10.3998/ark.5550190.p009.631

Reference yield:

1,2-dimethoxy-4-(2-propenyl)benzene (93-15-2) → 2-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)-ethylamino]-6,7-dimethoxy-[1,4]-naphthoquinone (457060-08-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 65 percent / sodium hydrogen carbonate / Pd(PPh₃)4 / dimethylformamide / 24 h / Heating

2: 76 percent / lithium diisopropylamide / tetrahydrofuran; hexane / 3 h / -78 - 20 °C

3: 62 percent / hydrogen peroxide; iodine; sulfuric acid / methanol / 4 h / 20 °C

4: 80 percent / ethanol / 24 h / 20 °C

With sulfuric acid; dihydrogen peroxide; iodine; sodium hydrogencarbonate; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; hexane; N,N-dimethyl-formamide; 1: Heck reaction;

DOI:10.1021/ol026074s

upstream raw materials:

2-(3,4-dimethoxyphenyl)-ethylamine

2-(3',4'-dimethoxyphenyl)-6,7-dimethoxy-1,4-dihydro-1,4-naphthalenedione

1,2-dimethoxy-4-(2-propenyl)benzene

2-(3',4'-dimethoxyphenyl)-6,7-dimethoxy-1-naphthol

Downstream raw materials:

permethyl ningalin C

1,4-bis-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)-ethyl]-9b-hydroxy-7,8-dimethoxy-1,9b-dihydro-3H-benzo[e]indole-2,5-dione