N'-hydroxy-4-(1,1,1-trifluoro-2-methylpropan-2-yl)benzenecarboximide amide

Base Information

Chemical Name:N'-hydroxy-4-(1,1,1-trifluoro-2-methylpropan-2-yl)benzenecarboximide amide
CAS No.:1225380-03-9
Molecular Formula:C₁₁H₁₃F₃N₂O
Molecular Weight:246.232
Hs Code.:

Synonyms:N'-hydroxy-4-(1,1,1-trifluoro-2-methylpropan-2-yl)benzenecarboximide amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N'-hydroxy-4-(1,1,1-trifluoro-2-methylpropan-2-yl)benzenecarboximide amide

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Technology Process of N'-hydroxy-4-(1,1,1-trifluoro-2-methylpropan-2-yl)benzenecarboximide amide

There total 6 articles about N'-hydroxy-4-(1,1,1-trifluoro-2-methylpropan-2-yl)benzenecarboximide amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1225380-06-2
4-(1,1,1-trifluoro-2-methylpropan-2-yl)benzenecarbonitrile

: 1225380-03-9
N'-hydroxy-4-(1,1,1-trifluoro-2-methylpropan-2-yl)benzenecarboximide amide

Guidance literature:: With hydroxylamine hydrochloride; triethylamine; In ethanol; for 1h; Reflux;

Reference yield: 96.0%

: 1225380-06-2
4-(1,1,1-trifluoro-2-methylpropan-2-yl)benzenecarbonitrile

: 5470-11-1
hydroxylamine hydrochloride

: 1225380-03-9
N'-hydroxy-4-(1,1,1-trifluoro-2-methylpropan-2-yl)benzenecarboximide amide

Guidance literature:: With triethylamine; In ethanol; for 1h; Reflux;

Reference yield:

: 16184-89-7
4'-bromo-2,2,2-trifluoroacetophenone

: 1225380-03-9
N'-hydroxy-4-(1,1,1-trifluoro-2-methylpropan-2-yl)benzenecarboximide amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane; n-heptane / 2.08 h / -40 - 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 20 - 40 °C / Inert atmosphere

2.2: 1 h / 40 °C

3.1: dichloromethane / 1.5 h / 0 - 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

5.1: hydroxylamine hydrochloride; triethylamine / ethanol / 1 h / Reflux

With hydroxylamine hydrochloride; sodium hydride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; n-heptane; dichloromethane; N,N-dimethyl-formamide; mineral oil;