Hydroxyammonium chloride

Base Information

• Chemical Name: Hydroxyammonium chloride
• CAS No.: 5470-11-1
• Deprecated CAS: 379722-73-3
• Molecular Formula: H3NO^.HCl
• Molecular Weight: 69.4909
• Hs Code.: 28251000
• DSSTox Substance ID: DTXSID7025425
• Wikidata: Q421356
• Mol file: 5470-11-1.mol

Synonyms:Hydroxyammonium chloride;DTXSID7025425;(N H3 (O H)) Cl;hydroxylammoniumchlorid;H4ClNO;Hydroxylaminhydrochlorid;Hydroxylammoniumchloride;hydoxylammonium chloride;hydroxy ammonium chloride;hydroxy-ammonium chloride;hydroxyl-ammonium chloride;UNII-5X4ZA62Z4Q;WCYJQVALWQMJGE-UHFFFAOYSA-M;hydroxyazanium chloride, AldrichCPR;Tox21_202970;AKOS024256075;NCGC00260516-01;CAS-5470-11-1;EC 226-798-2;Q421356

Chemical Property of Hydroxyammonium chloride

Chemical Property:

• Appearance/Colour: Colorless or off-white crystalline solid
• Vapor Pressure: 179mmHg at 25°C
• Melting Point: 155-158 °C
• Boiling Point: 56.5 °C at 760 mmHg
• PSA: 46.25000
• Density: 1.67 g/mL at 25 °C
• LogP: 0.83660
• Storage Temp.: Store at RT.
• Sensitive.: Hygroscopic
• Solubility.: 470g/l
• Water Solubility.: 560 g/L (20 ºC)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 68.9981414
• Heavy Atom Count: 3
• Complexity: 2

Purity/Quality:

98% ^*data from raw suppliers

Hydroxylamine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, N
• Hazard Codes: Xn,N,E
• Statements: 22-36/38-43-48/22-50-40-21/22-2
• Safety Statements: 22-24-37-61-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: [NH3+]O.[Cl-]
• Description: Hydroxylamine hydrochloride is a reducing agent that is routinely used for the deacetylation of SATA to form free sulfhydryls (Figure 1), for cleavage of protein cross‐linkers that contain carbonyl groups (i.e. EGS) and for mutagenesis of plasmid DNA.Hydroxylamine converts aldehydes and ketones (carbonyls) to their oxime derivative in weak bases, therefore cross‐linkers and other compounds with carbonyl groups are cleavable with Hydroxylamine hydrochloride.SATA and SATP are modification reagents that add a sulfhydryl group to primary amines on biomolecules. The initial modification results in the addition of an acetyl‐protected sulfur enabling storage of the biomolecule. To generate a free sulfhydryl the biomolecule is treated with hydroxylamine to remove the protecting acetyl group (see figure).EGS and sulfo‐EGS are homobifunctional, succinimidyl ester, amine reactive crosslinkers that are resistant to cleavage by denaturants used in SDS‐PAGE conditions, but may be cleaved with hydroxylamine.
• Physical properties: Colorless monoclinic crystals; hygroscopic; decomposes slowly in moist air;density 1.67 g/cm3at 17°C; melts at 151°C (decomposes); highly soluble inwater (84g/100g at 20°C); soluble in lower alcohols and glycols; pH of 0.1molar solution 3.4.
• Uses: Hydroxylamine hydrochloride is a monomoamine oxidase inhibitor. It is used to prepare oximes and hydroxmic acids in organic synthesis. It acts as a copolymerization inhibitor. It can be used to remove bromine and polybromide from a solution during extraction of lignin from lignocellulosic biomass. It is key starting material for the preparation of pharmaceuticals and agrochemicals. It plays a vital role in rubber and plastic industries as an antioxidant, a vulcanization accelerator and a radical scavenger. It is also used as a color stabilizer and emulsion additive in color films. Hydroxylammonium-chloride is a reducing agent in photography; in synthetic and analytical chemistry; as an antioxidant for fatty acids and soaps; in textiles; in medicine; controlled reduction reactions; non-discoloring short stoppers for synthetic rubbers; reagent for enzyme reactivation; powerful reducing agent; converts aldehydes and ketones to oximes and acid chlorides to hydroxamic acids; catalyst, swelling agent, and copolymerization inhibitor in polymerization processes; in floor lacquers and as an antioxidant for fatty acids and soaps.

Technology Process of Hydroxyammonium chloride

There total 49 articles about Hydroxyammonium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

Mo(NO)(NH2O)(C6H4S2C2H4S2C6H4)*C4H8O → {Mo(NO)(Cl)(dttd)} + hydroxylamine hydrochloride (5470-11-1)

Guidance literature:

With hydrogenchloride; In methanol; byproducts: NH4Cl, N2H5Cl; (N2); HCl bubbled through a soln. of the Mo-complex at 0°C for 15 min; soln. stirred for 1.5 h at room temp.; N2 bubbled through the suspn. for 15 min; ppt. filtered, washed with methanol and diethyl ether; recrystd. from hot THF;

Reference yield: 90.0%

ethyl nitrate (625-58-1) + tin(ll) chloride → hydroxylamine hydrochloride (5470-11-1) + ammonia (7664-41-7) + tin(IV) chloride (7646-78-8)

Guidance literature:

With hydrogenchloride; In hydrogenchloride; byproducts: C2H5OH, H2O; in concd. HCl soln.; evapn. of the alcohol,diluting with water,pptg. of the Sn with H2S,evapn. and crystn. from alcohol;

Reference yield: 90.0%

[Ni(II)(salicylaldehyde oximate)2] (54515-04-7,50897-08-0,14363-30-5) + ethylenediamine hydrochloride (18299-54-2) → Ni(C6H4(O)CHNC2H4NH2)2 + hydroxylamine hydrochloride (5470-11-1)

Guidance literature:

In methanol; stirring the soln. for 30 min between room temp. and 60°C, pptn.; filtration, washing with water, recrystn. from acetone;

DOI:10.1016/S0020-1693(00)83239-9

upstream raw materials:

(E,Z)-(4-chlorophenyl)(cyclopropyl)methanone oxime

hydrogen sulfide

nitrosylchloride

mercury fulminate

Downstream raw materials:

5-Amino-3-(1-hydroxy-1-methylpropyl)isoxazole

2-Methylthiobenzohydroxamic acid

hydroxylamine

1-(hydroxyimino)-1-(4-methoxybenzo(b)furane-2-yl)methylamine

Refernces

• 1、 Schoch, E. P.,Pritchett, R. H.. "". . p. 2042. Retrieved 1916.
• 2、 -. "Joint production technology of hydroxylamine, hydroxylammonium salt and cyclohexanone-oxime". Paragraph 0015; 0030; 0031. . Retrieved 2017/09/26.
• 3、 -. "Metalloprotease inhibitors". . . Retrieved 2008/06/13.