(R)-1-(2-chloro-5-oxo-6,7-dihydro-5H-5λ⁴-thieno[3,2-d]pyrimidin-4-ylamino)-1-(4-fluorophenyl)-2-methylpropan-2-ol

Base Information

• Chemical Name: (R)-1-(2-chloro-5-oxo-6,7-dihydro-5H-5λ⁴-thieno[3,2-d]pyrimidin-4-ylamino)-1-(4-fluorophenyl)-2-methylpropan-2-ol
• CAS No.: 1146361-96-7
• Molecular Formula: C₁₆H₁₇ClFN₃O₂S
• Molecular Weight: 369.847

Synonyms:(R)-1-(2-chloro-5-oxo-6,7-dihydro-5H-5λ⁴-thieno[3,2-d]pyrimidin-4-ylamino)-1-(4-fluorophenyl)-2-methylpropan-2-ol

Chemical Property of (R)-1-(2-chloro-5-oxo-6,7-dihydro-5H-5λ⁴-thieno[3,2-d]pyrimidin-4-ylamino)-1-(4-fluorophenyl)-2-methylpropan-2-ol

Chemical Property:

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Safty Information:

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Useful:

Technology Process of (R)-1-(2-chloro-5-oxo-6,7-dihydro-5H-5λ⁴-thieno[3,2-d]pyrimidin-4-ylamino)-1-(4-fluorophenyl)-2-methylpropan-2-ol

There total 7 articles about (R)-1-(2-chloro-5-oxo-6,7-dihydro-5H-5λ⁴-thieno[3,2-d]pyrimidin-4-ylamino)-1-(4-fluorophenyl)-2-methylpropan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-1-(2-chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-ylamino)-1-(4-fluorophenyl)-2-methylpropan-2-ol (1146361-95-6) → (R)-1-(2-chloro-5-oxo-6,7-dihydro-5H-5λ4-thieno[3,2-d]pyrimidin-4-ylamino)-1-(4-fluorophenyl)-2-methylpropan-2-ol (1146361-96-7)

Guidance literature:

(R)-1-(2-chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-ylamino)-1-(4-fluorophenyl)-2-methylpropan-2-ol; With dihydrogen peroxide; acetic acid; In water; at 10 ℃; for 1h;

With ammonia; water; at 0 ℃;

Reference yield:

(R)-1-(2-chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-ylamino)-1-(4-fluorophenyl)-2-methylpropan-2-ol (1146361-95-6) + 1,1'-bi-2-naphthol (602-09-5) → (R)-1-(2-chloro-5-oxo-6,7-dihydro-5H-5λ4-thieno[3,2-d]pyrimidin-4-ylamino)-1-(4-fluorophenyl)-2-methylpropan-2-ol (1146361-96-7)

Guidance literature:

With tert.-butylhydroperoxide; In decane; chloroform;

Reference yield:

methyl (R)-(4-fluorophenyl)-(2,2,2-trifluoracetylamino)-acetate (1146361-89-8) → (R)-1-(2-chloro-5-oxo-6,7-dihydro-5H-5λ4-thieno[3,2-d]pyrimidin-4-ylamino)-1-(4-fluorophenyl)-2-methylpropan-2-ol (1146361-96-7)

Guidance literature:

Multi-step reaction with 4 steps

1: ammonium chloride

2: KOH / water; methanol

3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane; water

4: tert.-butylhydroperoxide / chloroform; decane

With tert.-butylhydroperoxide; KOH; ammonium chloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; decane; chloroform; water;

upstream raw materials:

(R)-1-(2-chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-ylamino)-1-(4-fluorophenyl)-2-methylpropan-2-ol

1,1'-bi-2-naphthol

2,2,2-trifluoro-N-[(R)-1-(4-fluorophenyl)-2-hydroxy-2-methylpropyl]-acetamide

methyl (R)-(4-fluorophenyl)-(2,2,2-trifluoracetylamino)-acetate

Downstream raw materials:

4-(4-chlorophenyl)piperidine

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