4-(4-Chlorophenyl)piperidine

Base Information

• Chemical Name: 4-(4-Chlorophenyl)piperidine
• CAS No.: 26905-02-2
• Molecular Formula: C11H14ClN
• Molecular Weight: 195.692
• Hs Code.: 2933399090
• European Community (EC) Number: 833-592-1
• DSSTox Substance ID: DTXSID70360941
• Nikkaji Number: J779.597A
• Wikidata: Q72457360
• ChEMBL ID: CHEMBL2021650
• Mol file: 26905-02-2.mol

Synonyms:4-(4-chlorophenyl)piperidine;26905-02-2;4-(4-CHLORO-PHENYL)-PIPERIDINE;Piperidine, 4-(4-chlorophenyl)-;CHEMBL2011555;MFCD03077010;4-(4chlorophenyl)piperidine;4-(p-chlorophenyl)piperidine;SCHEMBL187003;4-(4-chlorophenyl)-piperidine;CHEMBL2021650;DTXSID70360941;BCP26512;AC-257;BDBM50379812;AKOS009171236;CS-W005284;SB36305;AS-37356;BP-11088;4-(4-chloro-phenyl)-piperidine, AldrichCPR;A5275;AM20040059;C3337;FT-0654052;(1-AMINOCYCLOHEXYL)METHYLAMINEDIHYDROCHLORIDE;Q-103005

Chemical Property of 4-(4-Chlorophenyl)piperidine

Chemical Property:

• Vapor Pressure: 0.00204mmHg at 25°C
• Melting Point: 0°C
• Refractive Index: 1.536
• Boiling Point: 290.7 °C at 760 mmHg
• PKA: 10.14±0.10(Predicted)
• Flash Point: 129.6 °C
• PSA: 12.03000
• Density: 1.095 g/cm³
• LogP: 3.93780
• Storage Temp.: 2-8°C(protect from light)
• Solubility.: soluble in Methanol
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 195.0814771
• Heavy Atom Count: 13
• Complexity: 146

Purity/Quality:

97% ^*data from raw suppliers

4-(4-Chlorophenyl)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1C2=CC=C(C=C2)Cl

Technology Process of 4-(4-Chlorophenyl)piperidine

There total 24 articles about 4-(4-Chlorophenyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N-benzyl-4-(4-chlorophenyl)-piperidine (143866-70-0) → 4-(4-chlorophenyl)piperidine (26905-02-2)

Guidance literature:

N-benzyl-4-(4-chlorophenyl)-piperidine; With carbonochloridic acid 1-chloro-ethyl ester; In 1,2-dichloro-ethane; for 2h; Heating;

With methanol; Heating;

DOI:10.1016/S0960-894X(00)00703-4

Reference yield: 70.0%

tert-butyl 4-(4-chlorophenyl)piperidine-1-carboxylate (946593-11-9) → 4-(4-chlorophenyl)piperidine (26905-02-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

4-(4-Chloro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (138647-50-4) → 4-(4-chlorophenyl)piperidine (26905-02-2)

Guidance literature:

4-(4-Chloro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester; With platinum(IV) oxide; hydrogen; In ethanol;

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1016/j.bmcl.2010.10.036

upstream raw materials:

N-benzyl-4-(4-chlorophenyl)-piperidine

1,2,3,6-tetrahydropyridine

chlorobenzene

4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine

Downstream raw materials:

1-[4-(4-Chloro-phenyl)-piperidin-1-yl]-3-(4-nitro-phenoxy)-propan-2-ol

{3-[4-(4-chlorophenyl)-piperidine-1-sulfonyl]-4-methyl-phenyl}-acetic acid ethyl ester

tert-Butyl 8-[3-[4-(4-chlorophenyl)-1-piperidinyl] propoxy]-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carboxylate

2-(4-(4-chlorophenyl)piperidin-1-yl)-8-hydroxynaphthalene-1,4-dione