3'-O-(N,N-diisopropylamino)phosphinoformic acid β-(diphenylmethylsilyl)ethyl ester 5'-O-di-p-anisylphenylmethyl-2'-deoxythymidine

Base Information

• Chemical Name: 3'-O-(N,N-diisopropylamino)phosphinoformic acid β-(diphenylmethylsilyl)ethyl ester 5'-O-di-p-anisylphenylmethyl-2'-deoxythymidine
• CAS No.: 887620-20-4
• Molecular Formula: C₅₃H₆₂N₃O₉PSi
• Molecular Weight: 944.149
• Mol file: 887620-20-4.mol

Synonyms:3'-O-(N,N-diisopropylamino)phosphinoformic acid β-(diphenylmethylsilyl)ethyl ester 5'-O-di-p-anisylphenylmethyl-2'-deoxythymidine

Chemical Property of 3'-O-(N,N-diisopropylamino)phosphinoformic acid β-(diphenylmethylsilyl)ethyl ester 5'-O-di-p-anisylphenylmethyl-2'-deoxythymidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-O-(N,N-diisopropylamino)phosphinoformic acid β-(diphenylmethylsilyl)ethyl ester 5'-O-di-p-anisylphenylmethyl-2'-deoxythymidine

There total 5 articles about 3'-O-(N,N-diisopropylamino)phosphinoformic acid β-(diphenylmethylsilyl)ethyl ester 5'-O-di-p-anisylphenylmethyl-2'-deoxythymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formic acid [bis(N,N-diisopropylamino)phosphino]-β-(diphenylmethylsilyl)ethyl ester (887620-19-1) + 5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) → 3'-O-(N,N-diisopropylamino)phosphinoformic acid β-(diphenylmethylsilyl)ethyl ester 5'-O-di-p-anisylphenylmethyl-2'-deoxythymidine (887620-20-4)

Guidance literature:

With 4,5-dicyano-1H-imidazole; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1021/ja060112b

Reference yield:

2-(methyldiphenylsilyl)ethyl chloroformate (887620-15-7) → 3'-O-(N,N-diisopropylamino)phosphinoformic acid β-(diphenylmethylsilyl)ethyl ester 5'-O-di-p-anisylphenylmethyl-2'-deoxythymidine (887620-20-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Na / tetrahydrofuran / 2 h / Heating

1.2: tetrahydrofuran / 1 h / 20 °C

2.1: 4.3 g / 4,5-dicyanoimidazole / CH₂Cl₂ / 4 h / 20 °C

With 4,5-dicyano-1H-imidazole; sodium; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja060112b

Reference yield:

bis(diisopropylamino)chlorophosphine (56183-63-2) → 3'-O-(N,N-diisopropylamino)phosphinoformic acid β-(diphenylmethylsilyl)ethyl ester 5'-O-di-p-anisylphenylmethyl-2'-deoxythymidine (887620-20-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: LiAlH₄ / tetrahydrofuran / 0.17 h / 0 °C

2.1: Na / tetrahydrofuran / 2 h / Heating

2.2: tetrahydrofuran / 1 h / 20 °C

3.1: 4.3 g / 4,5-dicyanoimidazole / CH₂Cl₂ / 4 h / 20 °C

With lithium aluminium tetrahydride; 4,5-dicyano-1H-imidazole; sodium; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja060112b

upstream raw materials:

formic acid [bis(N,N-diisopropylamino)phosphino]-β-(diphenylmethylsilyl)ethyl ester

5'-O-(4-4'-dimethoxytrityl)thymidine

2-(methyldiphenylsilyl)ethyl chloroformate

bis(diisopropylamino)chlorophosphine

Downstream raw materials:

C₆₃H₇₅N₄O₁₅PSi₂