formic acid [bis(N,N-diisopropylamino)phosphino]-β-(diphenylmethylsilyl)ethyl ester

Base Information

• Chemical Name: formic acid [bis(N,N-diisopropylamino)phosphino]-β-(diphenylmethylsilyl)ethyl ester
• CAS No.: 887620-19-1
• Molecular Formula: C₂₈H₄₅N₂O₂PSi
• Molecular Weight: 500.737
• Mol file: 887620-19-1.mol

Synonyms:formic acid [bis(N,N-diisopropylamino)phosphino]-β-(diphenylmethylsilyl)ethyl ester

Chemical Property of formic acid [bis(N,N-diisopropylamino)phosphino]-β-(diphenylmethylsilyl)ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of formic acid [bis(N,N-diisopropylamino)phosphino]-β-(diphenylmethylsilyl)ethyl ester

There total 3 articles about formic acid [bis(N,N-diisopropylamino)phosphino]-β-(diphenylmethylsilyl)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(methyldiphenylsilyl)ethyl chloroformate (887620-15-7) + bis(N,N-diisopropylamino)phosphine (86660-77-7) → formic acid [bis(N,N-diisopropylamino)phosphino]-β-(diphenylmethylsilyl)ethyl ester (887620-19-1)

Guidance literature:

bis(N,N-diisopropylamino)phosphine; With sodium; In tetrahydrofuran; for 2h; Heating;

2-(methyldiphenylsilyl)ethyl chloroformate; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1021/ja060112b

Reference yield:

bis(diisopropylamino)chlorophosphine (56183-63-2) → formic acid [bis(N,N-diisopropylamino)phosphino]-β-(diphenylmethylsilyl)ethyl ester (887620-19-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LiAlH₄ / tetrahydrofuran / 0.17 h / 0 °C

2.1: Na / tetrahydrofuran / 2 h / Heating

2.2: tetrahydrofuran / 1 h / 20 °C

With lithium aluminium tetrahydride; sodium; In tetrahydrofuran;

DOI:10.1021/ja060112b

Reference yield:

diphenylmethylsilylethylethanol (40438-48-0) → formic acid [bis(N,N-diisopropylamino)phosphino]-β-(diphenylmethylsilyl)ethyl ester (887620-19-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene

2.1: Na / tetrahydrofuran / 2 h / Heating

2.2: tetrahydrofuran / 1 h / 20 °C

With sodium; In tetrahydrofuran; toluene;

DOI:10.1021/ja060112b

upstream raw materials:

2-(methyldiphenylsilyl)ethyl chloroformate

bis(N,N-diisopropylamino)phosphine

bis(diisopropylamino)chlorophosphine

diphenylmethylsilylethylethanol

Downstream raw materials:

3'-O-(N,N-diisopropylamino)phosphinoformic acid β-(diphenylmethylsilyl)ethyl ester 5'-O-di-p-anisylphenylmethyl-2'-deoxythymidine

C₆₃H₇₅N₄O₁₅PSi₂

3'-O-(N,N-diisopropylamino)phosphinoformic acid β-(diphenylmethylsilyl)ethyl ester 5'-O-di-p-anisylphenylmethyl-N4-(9-fluorenylmethyloxycarbonyl)-2'-deoxycytidine