(R)-2-(7-{[1-(3,5-Dimethoxy-phenyl)-meth-(E)-ylidene]-amino}-1,1-dioxo-1,3,4,5-tetrahydro-1λ⁶-benzo[f][1,2,5]thiadiazepin-2-yl)-4-methyl-pentanoic acid tert-butyl ester

Base Information

• Chemical Name: (R)-2-(7-{[1-(3,5-Dimethoxy-phenyl)-meth-(E)-ylidene]-amino}-1,1-dioxo-1,3,4,5-tetrahydro-1λ⁶-benzo[f][1,2,5]thiadiazepin-2-yl)-4-methyl-pentanoic acid tert-butyl ester
• CAS No.: 238405-88-4
• Molecular Formula: C₂₇H₃₇N₃O₆S
• Molecular Weight: 531.673

Synonyms:(R)-2-(7-{[1-(3,5-Dimethoxy-phenyl)-meth-(E)-ylidene]-amino}-1,1-dioxo-1,3,4,5-tetrahydro-1λ⁶-benzo[f][1,2,5]thiadiazepin-2-yl)-4-methyl-pentanoic acid tert-butyl ester

Chemical Property of (R)-2-(7-{[1-(3,5-Dimethoxy-phenyl)-meth-(E)-ylidene]-amino}-1,1-dioxo-1,3,4,5-tetrahydro-1λ⁶-benzo[f][1,2,5]thiadiazepin-2-yl)-4-methyl-pentanoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (R)-2-(7-{[1-(3,5-Dimethoxy-phenyl)-meth-(E)-ylidene]-amino}-1,1-dioxo-1,3,4,5-tetrahydro-1λ⁶-benzo[f][1,2,5]thiadiazepin-2-yl)-4-methyl-pentanoic acid tert-butyl ester

There total 6 articles about (R)-2-(7-{[1-(3,5-Dimethoxy-phenyl)-meth-(E)-ylidene]-amino}-1,1-dioxo-1,3,4,5-tetrahydro-1λ⁶-benzo[f][1,2,5]thiadiazepin-2-yl)-4-methyl-pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dinitrobenzenesulfonyl chloride (1656-44-6) → (R)-2-(7-{[1-(3,5-Dimethoxy-phenyl)-meth-(E)-ylidene]-amino}-1,1-dioxo-1,3,4,5-tetrahydro-1λ6-benzo[f][1,2,5]thiadiazepin-2-yl)-4-methyl-pentanoic acid tert-butyl ester (238405-88-4)

Guidance literature:

Multi-step reaction with 5 steps

1: N-methylmorpholine / dioxane / 20 °C

2: diethyl azaodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C

3: Fe; aq. acetic acid / 1.5 h / 60 °C

4: N-methylmorpholine / dimethylformamide / 80 °C

5: ethanol / 5 h / 20 °C

With 4-methyl-morpholine; iron; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; 2: Mitsunobu reaction;

DOI:10.1021/jm020475w

Reference yield:

D-leucine t-butyl ester (67617-35-0) → (R)-2-(7-{[1-(3,5-Dimethoxy-phenyl)-meth-(E)-ylidene]-amino}-1,1-dioxo-1,3,4,5-tetrahydro-1λ6-benzo[f][1,2,5]thiadiazepin-2-yl)-4-methyl-pentanoic acid tert-butyl ester (238405-88-4)

Guidance literature:

Multi-step reaction with 5 steps

1: N-methylmorpholine / dioxane / 20 °C

2: diethyl azaodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C

3: Fe; aq. acetic acid / 1.5 h / 60 °C

4: N-methylmorpholine / dimethylformamide / 80 °C

5: ethanol / 5 h / 20 °C

With 4-methyl-morpholine; iron; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; 2: Mitsunobu reaction;

DOI:10.1021/jm020475w

Reference yield:

2-(2,4-dinitro-benzenesulfonylamino)-4-methyl-pentanoic acid tert-butyl ester (238405-77-1) → (R)-2-(7-{[1-(3,5-Dimethoxy-phenyl)-meth-(E)-ylidene]-amino}-1,1-dioxo-1,3,4,5-tetrahydro-1λ6-benzo[f][1,2,5]thiadiazepin-2-yl)-4-methyl-pentanoic acid tert-butyl ester (238405-88-4)

Guidance literature:

Multi-step reaction with 4 steps

1: diethyl azaodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C

2: Fe; aq. acetic acid / 1.5 h / 60 °C

3: N-methylmorpholine / dimethylformamide / 80 °C

4: ethanol / 5 h / 20 °C

With 4-methyl-morpholine; iron; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 1: Mitsunobu reaction;

DOI:10.1021/jm020475w

upstream raw materials:

3,5-dimethoxybenzaldehdye

2-(7-amino-1,1-dioxo-1,3,4,5-tetrahydro-1λ⁶-benzo[f][1,2,5]thiadiazepin-2-yl)-4-methyl-pentanoic acid tert-butyl ester

2,4-dinitrobenzenesulfonyl chloride

D-leucine t-butyl ester

Downstream raw materials:

tert-butyl (2R)-2-[7-[(3,5-dimethoxybenzyl)oxy]-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl]-4-methylpentanoate

2-[7-(3,5-dimethoxy-benzylamino)-1,1-dioxo-1,3,4,5-tetrahydro-1λ⁶-benzo[f][1,2,5]thiadiazepin-2-yl]-4-methyl-pentanoic acid

2-[7-(3,5-dimethoxy-benzylamino)-1,1-dioxo-1,3,4,5-tetrahydro-1λ⁶-benzo[f][1,2,5]thiadiazepin-2-yl]-4-methyl-pentanoic acid benzyloxy-amide

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