Technology Process of N-(4-chloro-3-cyclopropylaminomethyl-benzyl)-3,3,3-trifluoro-propionamide
There total 8 articles about N-(4-chloro-3-cyclopropylaminomethyl-benzyl)-3,3,3-trifluoro-propionamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-(4-chloro-3-formyl-benzyl)-3,3,3-trifluoro-propionamide; Cyclopropylamine;
In
methanol;
for 4h;
Heating / reflux;
With
sodium tetrahydroborate;
In
methanol;
at 20 ℃;
for 1h;
With
water; sodium hydrogencarbonate;
In
ethyl acetate;
- Guidance literature:
-
With
sodium tetrahydroborate;
In
methanol;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: -78 - 20 °C
2.1: sodium hydrogencarbonate / acetonitrile / 0.08 h
2.2: 0.17 h
3.1: lithium aluminium tetrahydride / diethyl ether / 1 h / 20 °C
3.2: 3 h
4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C
6.1: manganese(IV) oxide / acetonitrile / 4.5 h / 20 °C
7.1: methanol / 4 h / Heating / reflux
7.2: 1 h / 20 °C
With
manganese(IV) oxide; lithium aluminium tetrahydride; n-butyllithium; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; acetonitrile;
