3-amino-5-cyano-N-[2,6-dimethyl-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-phenyl]-benzamide

Base Information

Chemical Name:3-amino-5-cyano-N-[2,6-dimethyl-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-phenyl]-benzamide
CAS No.:1052118-73-6
Molecular Formula:C₂₂H₁₅Cl₃F₇N₃O₃
Molecular Weight:608.727
Hs Code.:

Synonyms:3-amino-5-cyano-N-[2,6-dimethyl-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-phenyl]-benzamide

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Chemical Property of 3-amino-5-cyano-N-[2,6-dimethyl-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-phenyl]-benzamide

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Technology Process of 3-amino-5-cyano-N-[2,6-dimethyl-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-phenyl]-benzamide

There total 3 articles about 3-amino-5-cyano-N-[2,6-dimethyl-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-phenyl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1033997-03-3
5-amino-3-cyano-N-[2,6-dimethyl-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-phenyl]-benzamide

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 1052118-73-6
3-amino-5-cyano-N-[2,6-dimethyl-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-phenyl]-benzamide

Guidance literature:: With pyridine; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 98556-65-1
3-cyano-5-nitrobenzoic acid

: 1052118-73-6
3-amino-5-cyano-N-[2,6-dimethyl-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-phenyl]-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 4 h / 20 °C / Reflux

2: pyridine / tetrahydrofuran / 12 h / 0 - 20 °C

3: hydrogenchloride; tin(ll) chloride / isopropyl alcohol; water / 0.5 h / 80 °C

4: pyridine / tetrahydrofuran / 2 h / 20 °C

With pyridine; hydrogenchloride; oxalyl dichloride; tin(ll) chloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol;

Reference yield:

: 618-84-8
3-amino-5-nitro-benzoic acid

: 1052118-73-6
3-amino-5-cyano-N-[2,6-dimethyl-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-phenyl]-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; sodium nitrite / water / 0 - 5 °C

1.2: 0 - 5 °C / pH 6 - 7

1.3: 0.67 h / 65 °C / Reflux

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 4 h / 20 °C / Reflux

3.1: pyridine / tetrahydrofuran / 12 h / 0 - 20 °C

4.1: hydrogenchloride; tin(ll) chloride / isopropyl alcohol; water / 0.5 h / 80 °C

5.1: pyridine / tetrahydrofuran / 2 h / 20 °C

With pyridine; hydrogenchloride; oxalyl dichloride; tin(ll) chloride; sodium nitrite; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol;