2-methyl-3-[2-(2-methyl-5-nitroimidazol-1-yl)ethylsulfanyl]benzyl chloride

Base Information

Chemical Name:2-methyl-3-[2-(2-methyl-5-nitroimidazol-1-yl)ethylsulfanyl]benzyl chloride
CAS No.:467252-70-6
Molecular Formula:C₁₄H₁₆ClN₃O₂S
Molecular Weight:325.819
Hs Code.:

Synonyms:2-methyl-3-[2-(2-methyl-5-nitroimidazol-1-yl)ethylsulfanyl]benzyl chloride

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Chemical Property of 2-methyl-3-[2-(2-methyl-5-nitroimidazol-1-yl)ethylsulfanyl]benzyl chloride

Chemical Property:

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Technology Process of 2-methyl-3-[2-(2-methyl-5-nitroimidazol-1-yl)ethylsulfanyl]benzyl chloride

There total 6 articles about 2-methyl-3-[2-(2-methyl-5-nitroimidazol-1-yl)ethylsulfanyl]benzyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 467252-65-9
2-methyl-3-[2-(2-methyl-5-nitroimidazol-1-yl)ethylsulfanyl]benzyl alcohol

: 467252-70-6
2-methyl-3-[2-(2-methyl-5-nitroimidazol-1-yl)ethylsulfanyl]benzyl chloride

Guidance literature:: With thionyl chloride; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/jm0208673

Reference yield:

: 1975-50-4
2-methyl-3-nitrobenzic acid

: 467252-70-6
2-methyl-3-[2-(2-methyl-5-nitroimidazol-1-yl)ethylsulfanyl]benzyl chloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: H₂ / Pd/C

2.1: NaNO₂; H⁺

2.2: potassium ethyl xanthogenate; aq. Na₂CO₃ / pH 8

2.3: 14.66 g / aq. NaOH / 20 h / Heating

3.1: 93 percent / H₂SO₄ / 48 h / Heating

4.1: 96 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

5.1: 56 percent / K₂CO₃ / 5 h / Heating

6.1: SOCl₂ / CH₂Cl₂ / 0.5 h / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; hydrogen; hydrogen cation; potassium carbonate; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0208673

Reference yield:

: 52130-17-3
3-amino-2-methylbenzoic acid

: 467252-70-6
2-methyl-3-[2-(2-methyl-5-nitroimidazol-1-yl)ethylsulfanyl]benzyl chloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaNO₂; H⁺

1.2: potassium ethyl xanthogenate; aq. Na₂CO₃ / pH 8

1.3: 14.66 g / aq. NaOH / 20 h / Heating

2.1: 93 percent / H₂SO₄ / 48 h / Heating

3.1: 96 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

4.1: 56 percent / K₂CO₃ / 5 h / Heating

5.1: SOCl₂ / CH₂Cl₂ / 0.5 h / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; hydrogen cation; potassium carbonate; sodium nitrite; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0208673