4-((4-chlorobenzyl)oxy)-1-(2-(2-(2-hydroxypropan-2-yl)cyclopropyl)-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one

Base Information

Chemical Name:4-((4-chlorobenzyl)oxy)-1-(2-(2-(2-hydroxypropan-2-yl)cyclopropyl)-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one
CAS No.:1447913-41-8
Molecular Formula:C₂₆H₂₆ClN₃O₃
Molecular Weight:463.964
Hs Code.:

Synonyms:4-((4-chlorobenzyl)oxy)-1-(2-(2-(2-hydroxypropan-2-yl)cyclopropyl)-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one

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Chemical Property of 4-((4-chlorobenzyl)oxy)-1-(2-(2-(2-hydroxypropan-2-yl)cyclopropyl)-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one

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Technology Process of 4-((4-chlorobenzyl)oxy)-1-(2-(2-(2-hydroxypropan-2-yl)cyclopropyl)-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one

There total 5 articles about 4-((4-chlorobenzyl)oxy)-1-(2-(2-(2-hydroxypropan-2-yl)cyclopropyl)-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1447913-44-1
ethyl 2-(6-(4-((4-chlorobenzyl)oxy)-2-oxopyridin-1(2H)-yl)-3-methylimidazo[1,2-a]pyridin-2-yl)cyclopropanecarboxylate

: 75-16-1
methylmagnesium bromide

: 1447913-41-8
4-((4-chlorobenzyl)oxy)-1-(2-(2-(2-hydroxypropan-2-yl)cyclopropyl)-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one

Guidance literature:: In tetrahydrofuran; diethyl ether; at 0 - 20 ℃;

Reference yield:

: 1447911-51-4
ethyl 6-iodo-3-methylimidazo[1,2-a]pyridine-2-carboxylic acid

: 1447913-41-8
4-((4-chlorobenzyl)oxy)-1-(2-(2-(2-hydroxypropan-2-yl)cyclopropyl)-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: diisobutylaluminium hydride / dichloromethane; toluene / 2 h / -78 °C

2: sodium hydride / mineral oil; tetrahydrofuran / 0 - 20 °C

3: 5,5-dimethyl-1,3-cyclohexadiene / 5 h / Reflux

4: potassium carbonate; copper(l) iodide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine / 1,4-dioxane / 12 h / 110 °C

5: tetrahydrofuran; diethyl ether / 0 - 20 °C

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; 5,5-dimethyl-1,3-cyclohexadiene; diethyl ether; dichloromethane; toluene; mineral oil;

Reference yield:

: 1447912-45-9
6-iodo-3-methylimidazo[1,2-a]pyridine-2-carbaldehyde

: 1447913-41-8
4-((4-chlorobenzyl)oxy)-1-(2-(2-(2-hydroxypropan-2-yl)cyclopropyl)-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / mineral oil; tetrahydrofuran / 0 - 20 °C

2: 5,5-dimethyl-1,3-cyclohexadiene / 5 h / Reflux

3: potassium carbonate; copper(l) iodide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine / 1,4-dioxane / 12 h / 110 °C

4: tetrahydrofuran; diethyl ether / 0 - 20 °C

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; sodium hydride; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; 5,5-dimethyl-1,3-cyclohexadiene; diethyl ether; mineral oil;