N-[4-chloro-3-(trifluoromethyl)phenyl]-[4-(N-methylformamide)(4-pyridyloxy)phenyl]thiourea toluenesulfonate

Base Information

Chemical Name:N-[4-chloro-3-(trifluoromethyl)phenyl]-[4-(N-methylformamide)(4-pyridyloxy)phenyl]thiourea toluenesulfonate
CAS No.:1246391-75-2
Molecular Formula:C₇H₈O₃S*C₂₁H₁₆ClF₃N₄O₂S
Molecular Weight:653.103
Hs Code.:

Synonyms:N-[4-chloro-3-(trifluoromethyl)phenyl]-[4-(N-methylformamide)(4-pyridyloxy)phenyl]thiourea toluenesulfonate

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Chemical Property of N-[4-chloro-3-(trifluoromethyl)phenyl]-[4-(N-methylformamide)(4-pyridyloxy)phenyl]thiourea toluenesulfonate

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Technology Process of N-[4-chloro-3-(trifluoromethyl)phenyl]-[4-(N-methylformamide)(4-pyridyloxy)phenyl]thiourea toluenesulfonate

There total 5 articles about N-[4-chloro-3-(trifluoromethyl)phenyl]-[4-(N-methylformamide)(4-pyridyloxy)phenyl]thiourea toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1229611-54-4
(4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)thioureido)phenoxy)-N-methylpyridine-2-carboxamide)

: 104-15-4
toluene-4-sulfonic acid

: 1246391-75-2
N-[4-chloro-3-(trifluoromethyl)phenyl]-[4-(N-methylformamide)(4-pyridyloxy)phenyl]thiourea toluenesulfonate

Guidance literature:: In ethanol; for 1.33333h; Reflux;

Reference yield:

: 220000-87-3
4-chloro-N-methylpicolinamide

: 1246391-75-2
N-[4-chloro-3-(trifluoromethyl)phenyl]-[4-(N-methylformamide)(4-pyridyloxy)phenyl]thiourea toluenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

1.2: 80 °C

2.1: dichloromethane / 20 °C / Inert atmosphere

3.1: ethanol / 1.33 h / Reflux

With potassium tert-butylate; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 98-98-6
2-Picolinic acid

: 1246391-75-2
N-[4-chloro-3-(trifluoromethyl)phenyl]-[4-(N-methylformamide)(4-pyridyloxy)phenyl]thiourea toluenesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / 40 - 72 °C

2.1: water; toluene / -5 - 20 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

3.2: 80 °C

4.1: dichloromethane / 20 °C / Inert atmosphere

5.1: ethanol / 1.33 h / Reflux

With thionyl chloride; potassium tert-butylate; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;