1-[3-(bromomethyl)-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-2-yl]ethan-1-one

Base Information

• Chemical Name: 1-[3-(bromomethyl)-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-2-yl]ethan-1-one
• CAS No.: 1003867-46-6
• Molecular Formula: C₁₅H₁₇BrClNO₂
• Molecular Weight: 358.662

Synonyms:1-[3-(bromomethyl)-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-2-yl]ethan-1-one

Chemical Property of 1-[3-(bromomethyl)-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-2-yl]ethan-1-one

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Technology Process of 1-[3-(bromomethyl)-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-2-yl]ethan-1-one

There total 2 articles about 1-[3-(bromomethyl)-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-2-yl]ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-(bromomethyl)-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazine (910916-64-2) + Acetyl bromide (506-96-7) → 1-[3-(bromomethyl)-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-2-yl]ethan-1-one (1003867-46-6)

Guidance literature:

With acetic anhydride; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1055/s-2007-990857

Reference yield: 84.0%

4-(4-chlorophenyl)-3,6,6-trimethyl-5,6-dihydro-4H-1,2-oxazine 2-oxide (929878-89-7) + Acetyl bromide (506-96-7) + acetic anhydride (108-24-7) → 1-[3-(bromomethyl)-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-2-yl]ethan-1-one (1003867-46-6)

Guidance literature:

In dichloromethane; at 20 ℃; for 3h;

DOI:10.1002/ejoc.201900131

Reference yield:

1-[3-(bromomethyl)-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-2-yl]ethan-1-one (1003867-46-6) → (E)-N-[1-(bromomethylene)-2-(4-chlorophenyl)prop-2-enyl]acetamide (1003867-64-8) + (Z)-N-[1-(bromomethylene)-2-(4-chlorophenyl)prop-2-enyl]acetamide (1003867-63-7)

Guidance literature:

In toluene; at 80 ℃; for 1h; Title compound not separated from byproducts.;

DOI:10.1055/s-2007-990857

upstream raw materials:

3-(bromomethyl)-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazine

Acetyl bromide

4-(4-chlorophenyl)-3,6,6-trimethyl-5,6-dihydro-4H-1,2-oxazine 2-oxide

acetic anhydride

Downstream raw materials:

(E)-N-[1-(bromomethylene)-2-(4-chlorophenyl)prop-2-enyl]acetamide

(Z)-N-[1-(bromomethylene)-2-(4-chlorophenyl)prop-2-enyl]acetamide

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