3-(bromomethyl)-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazine

Base Information

Chemical Name:3-(bromomethyl)-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazine
CAS No.:910916-64-2
Molecular Formula:C₁₃H₁₅BrClNO
Molecular Weight:316.625
Hs Code.:

Synonyms:3-(bromomethyl)-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazine

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Chemical Property of 3-(bromomethyl)-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazine

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Technology Process of 3-(bromomethyl)-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazine

There total 4 articles about 3-(bromomethyl)-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 929878-89-7
4-(4-chlorophenyl)-3,6,6-trimethyl-5,6-dihydro-4H-1,2-oxazine 2-oxide

: 910916-64-2
3-(bromomethyl)-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazine

Guidance literature:: 4-(4-chlorophenyl)-3,6,6-trimethyl-5,6-dihydro-4H-1,2-oxazine 2-oxide; With trimethylsilyl bromide; triethylamine; In dichloromethane; at 0 ℃; for 5h; Inert atmosphere;

With cobalt(II) bromide; In tetrahydrofuran; dichloromethane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1002/ejoc.201403083

Reference yield:

: 929878-89-7
4-(4-chlorophenyl)-3,6,6-trimethyl-5,6-dihydro-4H-1,2-oxazine 2-oxide

: 2857-97-8
trimethylsilyl bromide

: 910916-64-2
3-(bromomethyl)-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazine

Guidance literature:: With triethylamine; In dichloromethane; at -80 - -30 ℃; for 5h;
DOI:10.1016/j.btre.2020.e00438

Reference yield:

: 37629-52-0
(E)-1-(4-chlorophenyl)-2-nitropropene

: 910916-64-2
3-(bromomethyl)-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 83 percent / SnCl₄

2.1: TMSBr; Et₃N / CH₂Cl₂ / 1 h / -80 °C

2.2: 47 percent / MeCN / CH₂Cl₂ / 3 h / -30 °C

With trimethylsilyl bromide; tin(IV) chloride; triethylamine; In dichloromethane;
DOI:10.1055/s-2006-958930