((1S,2R,4R,6S)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-hydroxy-6-methylcyclohexyl)methyl acetate

Base Information

Chemical Name:((1S,2R,4R,6S)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-hydroxy-6-methylcyclohexyl)methyl acetate
CAS No.:1395285-72-9
Molecular Formula:C₂₁H₃₆N₂O₄Si
Molecular Weight:408.613
Hs Code.:

Synonyms:((1S,2R,4R,6S)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-hydroxy-6-methylcyclohexyl)methyl acetate

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Chemical Property of ((1S,2R,4R,6S)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-hydroxy-6-methylcyclohexyl)methyl acetate

Chemical Property:

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Technology Process of ((1S,2R,4R,6S)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-hydroxy-6-methylcyclohexyl)methyl acetate

There total 10 articles about ((1S,2R,4R,6S)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-hydroxy-6-methylcyclohexyl)methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (+/-)-((1S,2R,4R,6S)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-hydroxy-6-methylcyclohexyl)methyl acetate

: 1395280-32-6
((1R,2S,4S,6R)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-hydroxy-6-methylcyclohexyl)methyl acetate

: 1395285-72-9
((1S,2R,4R,6S)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-hydroxy-6-methylcyclohexyl)methyl acetate

Guidance literature:: With OJ column; In methanol; 2,2'-iminobis[ethanol];

Reference yield:

: 1187055-95-3
(±)-5-methyl-3-(3-nitropyridin-4-yl)cyclohex-2-enone

: 1395280-32-6
((1R,2S,4S,6R)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-hydroxy-6-methylcyclohexyl)methyl acetate

: 1395285-72-9
((1S,2R,4R,6S)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-hydroxy-6-methylcyclohexyl)methyl acetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / 0 - 20 °C

2.1: dichloromethane / 19 h / 0 - 20 °C

2.2: 0.33 h / 0 °C

2.3: 1 h / 0 °C

3.1: methyl iodide / tetrahydrofuran / 18 h / 0 - 20 °C

3.2: 5 h / 20 °C

4.1: sodium tetrahydroborate; methanol; cerium(III) chloride heptahydrate / 1.5 h / 0 - 20 °C

5.1: 1H-imidazole / dichloromethane / 18 h / 20 °C

6.1: 4-methylmorpholine N-oxide / osmium(VIII) oxide / water; acetone / 1 h / 20 °C

7.1: pyridine / dichloromethane / 0.25 h / 0 °C

8.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 18 h / 20 °C / Inert atmosphere

9.1: OJ column / 2,2'-iminobis[ethanol]; methanol

With pyridine; 1H-imidazole; methanol; sodium tetrahydroborate; cerium(III) chloride heptahydrate; hydrogen; 4-methylmorpholine N-oxide; lithium hexamethyldisilazane; methyl iodide; osmium(VIII) oxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; 2,2'-iminobis[ethanol]; acetone;

Reference yield:

: 1395280-12-2
(±)-6-((dimethylamino)methyl)-5-methyl-3-(3-nitropyridin-4-yl)cyclohex-2-enone

: 1395280-32-6
((1R,2S,4S,6R)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-hydroxy-6-methylcyclohexyl)methyl acetate

: 1395285-72-9
((1S,2R,4R,6S)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-hydroxy-6-methylcyclohexyl)methyl acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: methyl iodide / tetrahydrofuran / 18 h / 0 - 20 °C

1.2: 5 h / 20 °C

2.1: sodium tetrahydroborate; methanol; cerium(III) chloride heptahydrate / 1.5 h / 0 - 20 °C

3.1: 1H-imidazole / dichloromethane / 18 h / 20 °C

4.1: 4-methylmorpholine N-oxide / osmium(VIII) oxide / water; acetone / 1 h / 20 °C

5.1: pyridine / dichloromethane / 0.25 h / 0 °C

6.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 18 h / 20 °C / Inert atmosphere

7.1: OJ column / 2,2'-iminobis[ethanol]; methanol

With pyridine; 1H-imidazole; methanol; sodium tetrahydroborate; cerium(III) chloride heptahydrate; hydrogen; 4-methylmorpholine N-oxide; methyl iodide; osmium(VIII) oxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; 2,2'-iminobis[ethanol]; acetone;